Separation and detection of narcotic drugs on a microchip using micellar electrokinetic chromatography and electrochemiluminescence

David Attwood; Yan Du; Erkang Wang

doi:10.1002/elan.200704117

Separation and detection of narcotic drugs on a microchip using micellar electrokinetic chromatography and electrochemiluminescence

David Attwood, Yan Du, Erkang Wang

Research output: Contribution to journal › Article › peer-review

Abstract

A new approach for fast and sensitive electrochemiluminescence (ECL) detection of narcotic drugs on a microchip after separation by micellar electrokinetic chromatography (MEKC) is presented, taking the cocaine and its hydrolysate ecgonine as the test analytes. The mixture of hydrophilic BMIMBF4 ionic liquid (IL) and sodium dodecyl sulfate (SDS) was used directly as the buffer of MEKC with less noisy baselines, lower electrophoretic current and satisfactory separation performance. This developed microchip MEKC-ECL system was successfully applied to the determination of two very similar narcotics, heroin and codeine, within 100s in urine sample and was demonstrated as a promising method in clinical and forensic analysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	643-647
Number of pages	4
Journal	Electroanalysis
Volume	20
Issue number	6
DOIs	https://doi.org/10.1002/elan.200704117
Publication status	Published - Mar 2008

Keywords

Electrochemiluminescence (ECL)
Micellar electrokinetic chromatography (MEKC)
Microchip
Narcotic drugs

Access to Document

10.1002/elan.200704117

http://www3.interscience.wiley.com/cgi-bin/fulltext/117905320/PDFSTART

Cite this

@article{456a34320211474c8f3ceec97a4360cc,

title = "Separation and detection of narcotic drugs on a microchip using micellar electrokinetic chromatography and electrochemiluminescence",

abstract = "A new approach for fast and sensitive electrochemiluminescence (ECL) detection of narcotic drugs on a microchip after separation by micellar electrokinetic chromatography (MEKC) is presented, taking the cocaine and its hydrolysate ecgonine as the test analytes. The mixture of hydrophilic BMIMBF4 ionic liquid (IL) and sodium dodecyl sulfate (SDS) was used directly as the buffer of MEKC with less noisy baselines, lower electrophoretic current and satisfactory separation performance. This developed microchip MEKC-ECL system was successfully applied to the determination of two very similar narcotics, heroin and codeine, within 100s in urine sample and was demonstrated as a promising method in clinical and forensic analysis. {\textcopyright} 2008 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "Electrochemiluminescence (ECL), Micellar electrokinetic chromatography (MEKC), Microchip, Narcotic drugs",

author = "David Attwood and Yan Du and Erkang Wang",

year = "2008",

month = mar,

doi = "10.1002/elan.200704117",

language = "English",

volume = "20",

pages = "643--647",

journal = "Electroanalysis",

issn = "1521-4109",

publisher = "John Wiley & Sons Ltd",

number = "6",

}

TY - JOUR

T1 - Separation and detection of narcotic drugs on a microchip using micellar electrokinetic chromatography and electrochemiluminescence

AU - Attwood, David

AU - Du, Yan

AU - Wang, Erkang

PY - 2008/3

Y1 - 2008/3

N2 - A new approach for fast and sensitive electrochemiluminescence (ECL) detection of narcotic drugs on a microchip after separation by micellar electrokinetic chromatography (MEKC) is presented, taking the cocaine and its hydrolysate ecgonine as the test analytes. The mixture of hydrophilic BMIMBF4 ionic liquid (IL) and sodium dodecyl sulfate (SDS) was used directly as the buffer of MEKC with less noisy baselines, lower electrophoretic current and satisfactory separation performance. This developed microchip MEKC-ECL system was successfully applied to the determination of two very similar narcotics, heroin and codeine, within 100s in urine sample and was demonstrated as a promising method in clinical and forensic analysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - A new approach for fast and sensitive electrochemiluminescence (ECL) detection of narcotic drugs on a microchip after separation by micellar electrokinetic chromatography (MEKC) is presented, taking the cocaine and its hydrolysate ecgonine as the test analytes. The mixture of hydrophilic BMIMBF4 ionic liquid (IL) and sodium dodecyl sulfate (SDS) was used directly as the buffer of MEKC with less noisy baselines, lower electrophoretic current and satisfactory separation performance. This developed microchip MEKC-ECL system was successfully applied to the determination of two very similar narcotics, heroin and codeine, within 100s in urine sample and was demonstrated as a promising method in clinical and forensic analysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Electrochemiluminescence (ECL)

KW - Micellar electrokinetic chromatography (MEKC)

KW - Microchip

KW - Narcotic drugs

U2 - 10.1002/elan.200704117

DO - 10.1002/elan.200704117

M3 - Article

SN - 1521-4109

VL - 20

SP - 643

EP - 647

JO - Electroanalysis

JF - Electroanalysis

IS - 6

ER -

Separation and detection of narcotic drugs on a microchip using micellar electrokinetic chromatography and electrochemiluminescence

Abstract

Keywords

Access to Document

Fingerprint

Cite this