Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue

C. J. Chapman, D. K. Dünn-Walters, F. K. Stevenson, T. Hussell, P. G. Isaacson, J. Spencer

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Aim: To determine whether the immunoglobulin genes used by three gastric mucosa associated lymphoid tissue type lymphomas with known autoreactivity are mutated from germline as mutation from germline is an indicator of exposure to a mutational mechanism which characteristically acts on B cells as they undergo a follicle centre response. Methods: Cell lines established from two cases of MALT type lymphoma secrete autoantibodies recognising follicular dendritic cells (one case) and basement membrane (one case). The immunoglobulin heavy chain variable region genes (IgV(H)) and light chain variable region genes (IgV(L)) used by these cell lines, and the IgV(H) genes from a third case recognising human IgG were sequenced. Results: All three cases studied had mutated IgV(H) genes, while the IgV(L) genes were unmutated. Conclusion: The presence of mutations in IgV(H) genes is consistent with the origin of gastric MALT type lymphomas from B cells which have traversed the lymphoid follicle.
    Original languageEnglish
    Pages (from-to)M29-M32
    JournalJournal of Clinical Pathology
    Volume49
    Issue number1
    Publication statusPublished - 1996

    Keywords

    • Gastric lymphoma
    • Mucosa associated lymphoid tissue type lymphoma
    • Mutation

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