Sequence variation of the human Y chromosome

L. S. Whitfield; J. E. Sulston; P. N. Goodfellow

doi:10.1038/378379a0

Sequence variation of the human Y chromosome

L. S. Whitfield, J. E. Sulston, P. N. Goodfellow

Research output: Contribution to journal › Article › peer-review

Abstract

We have generated over 100 kilobases of sequence from the non-recombining portion of the Y chromosomes from five humans and one common chimpanzee. The human subjects were chosen to match the earliest branches of the human mitochondrial tree. The survey of 18.3 kilobases from each human detected only three sites at which substitutions were present, whereas the human and chimpanzee sequences showed 1.3% divergence. The coalescence time estimated from our Y chromosome sample is more recent than that of the mitochondrial genome. A recent coalescence time for the Y chromosome could have been caused by the selected sweep of an advantageous Y chromosome or extensive migration of human males.

Original language	English
Pages (from-to)	379-380
Number of pages	1
Journal	Nature
Volume	378
Issue number	6555
DOIs	https://doi.org/10.1038/378379a0
Publication status	Published - 1995

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abstract = "We have generated over 100 kilobases of sequence from the non-recombining portion of the Y chromosomes from five humans and one common chimpanzee. The human subjects were chosen to match the earliest branches of the human mitochondrial tree. The survey of 18.3 kilobases from each human detected only three sites at which substitutions were present, whereas the human and chimpanzee sequences showed 1.3% divergence. The coalescence time estimated from our Y chromosome sample is more recent than that of the mitochondrial genome. A recent coalescence time for the Y chromosome could have been caused by the selected sweep of an advantageous Y chromosome or extensive migration of human males.",

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AU - Goodfellow, P. N.

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AB - We have generated over 100 kilobases of sequence from the non-recombining portion of the Y chromosomes from five humans and one common chimpanzee. The human subjects were chosen to match the earliest branches of the human mitochondrial tree. The survey of 18.3 kilobases from each human detected only three sites at which substitutions were present, whereas the human and chimpanzee sequences showed 1.3% divergence. The coalescence time estimated from our Y chromosome sample is more recent than that of the mitochondrial genome. A recent coalescence time for the Y chromosome could have been caused by the selected sweep of an advantageous Y chromosome or extensive migration of human males.

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DO - 10.1038/378379a0

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Sequence variation of the human Y chromosome

Abstract

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