Sequencing therapies in Hodgkin lymphoma

Elizabeth Phillips, Graham P Collins, Kate Cwynarski

Research output: Contribution to journalComment/debatepeer-review

Abstract

Classical Hodgkin lymphoma is a highly curable malignancy, but challenges persist for how best to treat patients who are refractory to or relapse after first-line therapy. Multiagent induction chemotherapy followed by high-dose therapy with autologous haematopoietic stem-cell transplantation (HSCT) has been considered the standard of care for second-line treatment of Hodgkin lymphoma since the early 1990s. Since then, practice has evolved with the introduction of 18-fluorodeoxglucose PET imaging for response assessment, with autologous HSCT largely reserved for patients who have a complete metabolic response, or at least good partial response, to reinduction chemotherapy. However, there has otherwise been little change in therapeutic approaches to second-line treatment over the past few decades, despite the emergence of several effective targeted agents.
Original languageEnglish
Pages (from-to)e537-e539
JournalThe Lancet Haematology
Volume8
Issue number8
DOIs
Publication statusPublished - 1 Aug 2021

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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