TY - JOUR
T1 - Sequential platinum-based chemotherapy-thoracic radiotherapy in early stage non-small cell lung cancer.
AU - Thatcher, Nick
AU - Faivre-Finn, Corinne
AU - Blackhall, Fiona
AU - Anderson, Heather
AU - Lorigan, Paul
PY - 2005/7/1
Y1 - 2005/7/1
N2 - Combined chemoradiotherapy (CTRT) is intended to reduce the risk of local regional recurrence and distant relapse in patients with early stage non-small cell lung cancer (NSCLC). Sequential CTRT allows full doses of each modality while avoiding the additive toxicity that occurs with concurrent therapy. This review will encompass studies in the three main settings where sequential CTRT has been applied in early stage NSCLC: as adjuvant therapy after resection, as neoadjuvant chemotherapy and surgery followed by radiotherapy, and in unresectable stage III disease.
AB - Combined chemoradiotherapy (CTRT) is intended to reduce the risk of local regional recurrence and distant relapse in patients with early stage non-small cell lung cancer (NSCLC). Sequential CTRT allows full doses of each modality while avoiding the additive toxicity that occurs with concurrent therapy. This review will encompass studies in the three main settings where sequential CTRT has been applied in early stage NSCLC: as adjuvant therapy after resection, as neoadjuvant chemotherapy and surgery followed by radiotherapy, and in unresectable stage III disease.
KW - therapeutic use: Antineoplastic Combined Chemotherapy Protocols
KW - drug therapy: Carcinoma, Non-Small-Cell Lung
KW - administration & dosage: Cisplatin
KW - Combined Modality Therapy
KW - Dose Fractionation
KW - Drug Administration Schedule
KW - Humans
KW - drug therapy: Lung Neoplasms
KW - Neoadjuvant Therapy
U2 - 10.1158/1078-0432.CCR-05-9004
DO - 10.1158/1078-0432.CCR-05-9004
M3 - Article
VL - 11
JO - Clinical cancer research : an official journal of the American Association for Cancer Research
JF - Clinical cancer research : an official journal of the American Association for Cancer Research
SN - 1078-0432
IS - 13
ER -
