Serum levels of CA 125 during the first trimester of normal outcome, ectopic and anembryonic pregnancies

I. J. Jacobs, T. N. Fay, J. Yovich, I. Stabile, C. Frost, J. Turner, D. H. Oram, J. G. Grudzinskas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Single serum samples were obtained during the first trimester of pregnancies with a retrospectively normal outcome (n = 150), ectopic pregnancies (n = 38) and anembryonic pregnancies (n = 78). Serial samples during the first trimester were also obtained from 43 women achieving pregnancy following successful treatment for infertility and with a retrospectively defined normal outcome. Significant variation in serum CA 125 levels in relation to gestational age was observed in pregnancies with a normal outcome (P <0.0001). Peak serum CA 125 levels were observed at 6 - 7 weeks, the mean level at this gestation being 40.1 U/ml (range 31.7 - 50.7 U/ml) in the normal conception/normal outcome group and 36.5 U/ml (range 25.6 - 52.0 U/ml) in the assisted conception/normal outcome group. A rise and fall in serum CA 125 levels during the first trimester was observed in 42 of 43 assisted conceptions monitored serially, with peak levels ranging from 7 to 1398 U/ml (medium 48.8 U/ml) occurring at 28 - 61 days (median 45 days) gestation. Mean serum CA 125 levels were higher in the anembryonic pregnancy group at 4 - 5 and 6 - 7 weeks gestation than in both normal pregnancy outcome groups (P <0.01).
    Original languageEnglish
    Pages (from-to)116-122
    Number of pages6
    JournalHuman Reproduction
    Volume5
    Issue number1
    Publication statusPublished - 1990

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