Serum MUC5AC mucin as a potential marker for cholangiocarcinoma

Sopit Wongkham; John Kieran Sheehan; Chanchai Boonla; Siriporn Patrakitkomjorn; Marjorie Howard; Sara Kirkham; Banchob Sripa; Chaisiri Wongkham; Vajarabhongsa Bhudhisawasdi

doi:10.1016/S0304-3835(02)00691-2

Serum MUC5AC mucin as a potential marker for cholangiocarcinoma

Sopit Wongkham, John Kieran Sheehan, Chanchai Boonla, Siriporn Patrakitkomjorn, Marjorie Howard, Sara Kirkham, Banchob Sripa, Chaisiri Wongkham, Vajarabhongsa Bhudhisawasdi

Research output: Contribution to journal › Article › peer-review

Abstract

Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinoma patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	93-99
Number of pages	6
Journal	Cancer Letters
Volume	195
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(02)00691-2
Publication status	Published - 30 May 2003

Keywords

Bile duct
Cholangiocarcinoma
MUC5AC
Mucin
Tumor marker

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(02)00691-2

Cite this

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title = "Serum MUC5AC mucin as a potential marker for cholangiocarcinoma",

abstract = "Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinoma patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma. {\textcopyright} 2002 Elsevier Science Ireland Ltd. All rights reserved.",

keywords = "Bile duct, Cholangiocarcinoma, MUC5AC, Mucin, Tumor marker",

author = "Sopit Wongkham and Sheehan, {John Kieran} and Chanchai Boonla and Siriporn Patrakitkomjorn and Marjorie Howard and Sara Kirkham and Banchob Sripa and Chaisiri Wongkham and Vajarabhongsa Bhudhisawasdi",

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T1 - Serum MUC5AC mucin as a potential marker for cholangiocarcinoma

AU - Wongkham, Sopit

AU - Sheehan, John Kieran

AU - Boonla, Chanchai

AU - Patrakitkomjorn, Siriporn

AU - Howard, Marjorie

AU - Kirkham, Sara

AU - Sripa, Banchob

AU - Wongkham, Chaisiri

AU - Bhudhisawasdi, Vajarabhongsa

PY - 2003/5/30

Y1 - 2003/5/30

N2 - Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinoma patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

AB - Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinoma patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

KW - Bile duct

KW - Cholangiocarcinoma

KW - MUC5AC

KW - Mucin

KW - Tumor marker

U2 - 10.1016/S0304-3835(02)00691-2

DO - 10.1016/S0304-3835(02)00691-2

M3 - Article

C2 - 12767517

SN - 1872-7980

VL - 195

SP - 93

EP - 99

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Serum MUC5AC mucin as a potential marker for cholangiocarcinoma

Abstract

Keywords

UN SDGs

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