Serum oestrogen receptor α and Β bioactivity are independently associated with breast cancer: a proof of principle study

M. Widschwendter, H. Lichtenberg-Frate, G. Hasenbrink, S. Schwarzer, A. Dawnay, A. Lam, U. Menon, S. Apostolidou, E. Raum, C. Stegmaier, I. J. Jacobs, H. Brenner

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background:Oestrogens play a crucial role in breast carcinogenesis. Earlier studies have analysed the serum levels of endogenous hormones measured by conventional assays. In this study, we analysed the capacity of serum from breast cancer cases and controls to transactivate the oestrogen receptor α (ER-α) and Β (ER-Β).Methods:We used a receptor oestrogen-responsive element (ERE) - the green fluorescent protein (GFP)-reporter test system in Saccharomyces cerevisiae. Oestrogen receptor-α or ER-Β bioactivity was determined in serum from 182 randomly chosen postmenopausal women with breast cancer and from 188 age-matched controls.Results:High serum ER-α and ER-Β bioactivity were independently associated with the presence of breast cancer. Women whose levels of serum ER-α and ER-Β bioactivity were in the highest quintile among controls had a 7.57-(95% confidence interval (CI): 2.46-23.32; P0.0004) and a 10.14 (95% CI: 3.19-32.23; P0.0001)-fold risk for general and oestrogen receptor-positive breast cancer, respectively.Conclusion:The use of serum ER-α and ER-Β bioactivity assays as clinical tools in the management of breast cancer warrants further research. Future studies will dictate whether surrogate markers of ER-α and ER-Β bioactivity will provide a means to monitor the efficacy of anti-endocrine, adjuvant and chemopreventive strategies. © 2009 Cancer Research.
    Original languageEnglish
    Pages (from-to)160-165
    Number of pages5
    JournalBritish Journal of Cancer
    Volume101
    Issue number1
    DOIs
    Publication statusPublished - 7 Jul 2009

    Keywords

    • Breast cancer
    • Oestrogen receptor
    • Risk
    • Serum bioactivity

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