Serum phosphorus levels associate with coronary atherosclerosis in young adults

Robert N. Foley; Allan J. Collins; Charles A. Herzog; Areef Ishani; Philip A. Kalra

doi:10.1681/ASN.2008020141

Serum phosphorus levels associate with coronary atherosclerosis in young adults

Robert N. Foley, Allan J. Collins, Charles A. Herzog, Areef Ishani, Philip A. Kalra

Research output: Contribution to journal › Article › peer-review

Abstract

Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown. This study aimed to determine whether an association exists between phosphorus levels and coronary artery calcium levels in a community-based cohort of 3015 healthy young adults in the prospective Coronary Artery Risk Development in Young Adults (CARDIA) study. Phosphorus levels were measured at baseline, and presence of coronary artery calcium was assessed by computed tomography 15 yr later. Mean age at study inception was 25.2 yr, and the mean levels of phosphorus and calcium were 3.6 and 9.5 mg/dl, respectively. Only 0.2% of participants had estimated GFR

Original language	English
Pages (from-to)	397-404
Number of pages	7
Journal	Journal of the American Society of Nephrology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1681/ASN.2008020141
Publication status	Published - Feb 2009

Keywords

Adolescent
Adult
diagnosis: Calcinosis
Cohort Studies
blood: Coronary Artery Disease
Female
Glomerular Filtration Rate
Humans
Male
Odds Ratio
blood: Phosphorus
Prospective Studies
Risk
Tomography, X-Ray Computed
Young Adult

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10.1681/ASN.2008020141

http://jasn.asnjournals.org/cgi/reprint/20/2/397

Cite this

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title = "Serum phosphorus levels associate with coronary atherosclerosis in young adults",

abstract = "Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown. This study aimed to determine whether an association exists between phosphorus levels and coronary artery calcium levels in a community-based cohort of 3015 healthy young adults in the prospective Coronary Artery Risk Development in Young Adults (CARDIA) study. Phosphorus levels were measured at baseline, and presence of coronary artery calcium was assessed by computed tomography 15 yr later. Mean age at study inception was 25.2 yr, and the mean levels of phosphorus and calcium were 3.6 and 9.5 mg/dl, respectively. Only 0.2% of participants had estimated GFR",

keywords = "Adolescent, Adult, diagnosis: Calcinosis, Cohort Studies, blood: Coronary Artery Disease, Female, Glomerular Filtration Rate, Humans, Male, Odds Ratio, blood: Phosphorus, Prospective Studies, Risk, Tomography, X-Ray Computed, Young Adult",

author = "Foley, {Robert N.} and Collins, {Allan J.} and Herzog, {Charles A.} and Areef Ishani and Kalra, {Philip A.}",

year = "2009",

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doi = "10.1681/ASN.2008020141",

language = "English",

volume = "20",

pages = "397--404",

journal = "Journal of the American Society of Nephrology",

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publisher = "American Society of Nephrology",

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TY - JOUR

T1 - Serum phosphorus levels associate with coronary atherosclerosis in young adults

AU - Foley, Robert N.

AU - Collins, Allan J.

AU - Herzog, Charles A.

AU - Ishani, Areef

AU - Kalra, Philip A.

PY - 2009/2

Y1 - 2009/2

N2 - Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown. This study aimed to determine whether an association exists between phosphorus levels and coronary artery calcium levels in a community-based cohort of 3015 healthy young adults in the prospective Coronary Artery Risk Development in Young Adults (CARDIA) study. Phosphorus levels were measured at baseline, and presence of coronary artery calcium was assessed by computed tomography 15 yr later. Mean age at study inception was 25.2 yr, and the mean levels of phosphorus and calcium were 3.6 and 9.5 mg/dl, respectively. Only 0.2% of participants had estimated GFR

AB - Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown. This study aimed to determine whether an association exists between phosphorus levels and coronary artery calcium levels in a community-based cohort of 3015 healthy young adults in the prospective Coronary Artery Risk Development in Young Adults (CARDIA) study. Phosphorus levels were measured at baseline, and presence of coronary artery calcium was assessed by computed tomography 15 yr later. Mean age at study inception was 25.2 yr, and the mean levels of phosphorus and calcium were 3.6 and 9.5 mg/dl, respectively. Only 0.2% of participants had estimated GFR

KW - Adolescent

KW - Adult

KW - diagnosis: Calcinosis

KW - Cohort Studies

KW - blood: Coronary Artery Disease

KW - Female

KW - Glomerular Filtration Rate

KW - Humans

KW - Male

KW - Odds Ratio

KW - blood: Phosphorus

KW - Prospective Studies

KW - Risk

KW - Tomography, X-Ray Computed

KW - Young Adult

U2 - 10.1681/ASN.2008020141

DO - 10.1681/ASN.2008020141

M3 - Article

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EP - 404

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

IS - 2

ER -

Serum phosphorus levels associate with coronary atherosclerosis in young adults

Abstract

Keywords

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