Serum phosphorus levels associate with coronary atherosclerosis in young adults

Robert N. Foley, Allan J. Collins, Charles A. Herzog, Areef Ishani, Philip A. Kalra

    Research output: Contribution to journalArticlepeer-review


    Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown. This study aimed to determine whether an association exists between phosphorus levels and coronary artery calcium levels in a community-based cohort of 3015 healthy young adults in the prospective Coronary Artery Risk Development in Young Adults (CARDIA) study. Phosphorus levels were measured at baseline, and presence of coronary artery calcium was assessed by computed tomography 15 yr later. Mean age at study inception was 25.2 yr, and the mean levels of phosphorus and calcium were 3.6 and 9.5 mg/dl, respectively. Only 0.2% of participants had estimated GFR
    Original languageEnglish
    Pages (from-to)397-404
    Number of pages7
    JournalJournal of the American Society of Nephrology
    Issue number2
    Publication statusPublished - Feb 2009


    • Adolescent
    • Adult
    • diagnosis: Calcinosis
    • Cohort Studies
    • blood: Coronary Artery Disease
    • Female
    • Glomerular Filtration Rate
    • Humans
    • Male
    • Odds Ratio
    • blood: Phosphorus
    • Prospective Studies
    • Risk
    • Tomography, X-Ray Computed
    • Young Adult


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