Projects per year
Abstract
Objectives: To determine if blood prestin level changes after exposure to music at high sound pressure levels, and if this change is associated with temporary threshold shift (TTS) and/or changes in distortion product (DP) amplitude.
Design: Participants were exposed to pop-rock music at 100 dBA for 15 minutes monaurally through headphones. Pure tone audiometry, DP amplitude, and blood prestin level were measured before and after exposure.
Results: Fourteen adults [nine women; age range: 20-54 years, median age=31 (IQR=6.75)] with normal hearing were included in the study. Mean prestin level increased shortly after exposure to music, then returned to baseline within 1 week, although this trend was not observed in all participants. All participants presented TTS or a decrease in DP amplitude in at least one frequency after music exposure. There was a statistically significant average threshold elevation at 4 minutes post-exposure. Statistically significant DP amplitude shifts were observed at 4 and 6 kHz, 2 minutes following exposure. Mean baseline serum prestin level [mean: 140.00 pg/ml, 95% CI: (125.92, 154.07)] progressively increased following music exposure, reaching a maximum at 2 hours [mean: 158.29 pg/ml, 95% CI: (130.42, 186.66)] and returned to pre-exposure level at 1 week [mean: 139.18 pg/ml, 95% CI: (114.69, 163.68)]. However, after correction for multiple comparisons, mean prestin level showed no statistically significant increase from baseline at any timepoint. No correlation between maximum blood prestin level change and average TTS or DPOAE amplitude shift was found. However, in an exploratory analysis, TTS at 6 kHz (the frequency at which maximum TTS occurred) decreased significantly as baseline blood prestin level 27 increased.
Conclusions: The results suggest that blood prestin level may change after exposure to music at high sound pressure levels, although statistical significance was not reached in this relatively small sample after correction. Baseline serum prestin level may also predict the degree of TTS. These findings thus suggest that the role of baseline serum prestin level as a proxy marker of cochlear susceptibility to intense music exposure should be further explored.
Design: Participants were exposed to pop-rock music at 100 dBA for 15 minutes monaurally through headphones. Pure tone audiometry, DP amplitude, and blood prestin level were measured before and after exposure.
Results: Fourteen adults [nine women; age range: 20-54 years, median age=31 (IQR=6.75)] with normal hearing were included in the study. Mean prestin level increased shortly after exposure to music, then returned to baseline within 1 week, although this trend was not observed in all participants. All participants presented TTS or a decrease in DP amplitude in at least one frequency after music exposure. There was a statistically significant average threshold elevation at 4 minutes post-exposure. Statistically significant DP amplitude shifts were observed at 4 and 6 kHz, 2 minutes following exposure. Mean baseline serum prestin level [mean: 140.00 pg/ml, 95% CI: (125.92, 154.07)] progressively increased following music exposure, reaching a maximum at 2 hours [mean: 158.29 pg/ml, 95% CI: (130.42, 186.66)] and returned to pre-exposure level at 1 week [mean: 139.18 pg/ml, 95% CI: (114.69, 163.68)]. However, after correction for multiple comparisons, mean prestin level showed no statistically significant increase from baseline at any timepoint. No correlation between maximum blood prestin level change and average TTS or DPOAE amplitude shift was found. However, in an exploratory analysis, TTS at 6 kHz (the frequency at which maximum TTS occurred) decreased significantly as baseline blood prestin level 27 increased.
Conclusions: The results suggest that blood prestin level may change after exposure to music at high sound pressure levels, although statistical significance was not reached in this relatively small sample after correction. Baseline serum prestin level may also predict the degree of TTS. These findings thus suggest that the role of baseline serum prestin level as a proxy marker of cochlear susceptibility to intense music exposure should be further explored.
| Original language | English |
|---|---|
| Journal | Ear and hearing |
| Publication status | Accepted/In press - 9 Feb 2024 |
Keywords
- word
- music
- temporary shift
- prestin
- biomaker
- pure tone audiometry
- distortion product otoacoustic emmissions
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NIHR Manchester Biomedical Research Centre
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Manchester Centre for Audiology and Deafness (ManCAD)
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Project: Research