TY - JOUR
T1 - Serum uric acid is associated with carotid plaques: The National Heart, Lung, and Blood Institute Family Heart Study
AU - Neogi, Tuhina
AU - Ellison, R. Curtis
AU - Hunt, Steven
AU - Terkeltaub, Robert
AU - Felson, David T.
AU - Zhang, Yuqing
N1 - 1K23AR055127, AR, NIAMS NIH HHS, United StatesAR 47785, AR, NIAMS NIH HHS, United StatesHL077360, HL, NHLBI NIH HHS, United StatesK23 AR055127-01, AR, NIAMS NIH HHS, United StatesK23 AR055127-02, AR, NIAMS NIH HHS, United StatesR01 HL077360-04, HL, NHLBI NIH HHS, United StatesU01 HL56563, HL, NHLBI NIH HHS, United StatesU01 HL56564, HL, NHLBI NIH HHS, United StatesU01 HL56565, HL, NHLBI NIH HHS, United StatesU01 HL56566, HL, NHLBI NIH HHS, United StatesU01 HL56567, HL, NHLBI NIH HHS, United StatesU01 HL56568, HL, NHLBI NIH HHS, United StatesU01 HL56569, HL, NHLBI NIH HHS, United States
PY - 2009/2
Y1 - 2009/2
N2 - Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories <5 (reference), 5 to <6, 6 to <6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology Copyright © 2009. All rights reserved.
AB - Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories <5 (reference), 5 to <6, 6 to <6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology Copyright © 2009. All rights reserved.
KW - Carotid atherosclerosis
KW - Epidemiology
KW - Risk factors
KW - Uric acid
U2 - 10.3899/jrheum.080646
DO - 10.3899/jrheum.080646
M3 - Article
C2 - 19012359
SN - 1499-2752
VL - 36
SP - 378
EP - 384
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 2
ER -
