Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

Sachiyo Yoshida; José Martines; Joy E Lawn; Stephen Wall; Joăo Paulo Souza; Igor Rudan; Simon Cousens; Peter Aaby; Ishag Adam; Ramesh Kant Adhikari; Namasivayam Ambalavanan; Shams Ei Arifeen; Dhana Raj Aryal; Sk Asiruddin; Abdullah Baqui; Aluisio Jd Barros; Christine S Benn; Vineet Bhandari; Shinjini Bhatnagar; Sohinee Bhattacharya; Zulfiqar A Bhutta; Robert E Black; Hannah Blencowe; Carl Bose; Justin Brown; Christoph Bührer; Wally Carlo; Jose Guilherme Cecatti; Po-Yin Cheung; Robert Clark; Tim Colbourn; Agustin Conde-Agudelo; Erica Corbett; Andrew E Czeizel; Abhik Das; Louise Tina Day; Carolyn Deal; Ashok Deorari; Uğur Dilmen; Mike English; Cyril Engmann; Fabian Esamai; Caroline Fall; Donna M Ferriero; Peter Gisore; Tabish Hazir; Rosemary D Higgins; Caroline Se Homer; D E Hoque; Lorentz Irgens; M T Islam; Joseph de Graft-Johnson; Martias Alice Joshua; William Keenan; Soofia Khatoon; Helle Kieler; Michael S Kramer; Eve M Lackritz; Tina Lavender; Laurensia Lawintono; Richard Luhanga; David Marsh; Douglas McMillan; Patrick J McNamara; Ben Willem J Mol; Elizabeth Molyneux; G K Mukasa; Miriam Mutabazi; Luis Carlos Nacul; Margaret Nakakeeto; Indira Narayanan; Bolajoko Olusanya; David Osrin; Vinod Paul; Christian Poets; Uma M Reddy; Mathuram Santosham; Rubayet Sayed; Natalia E Schlabritz-Loutsevitch; Nalini Singhal; Mary Alice Smith; Peter G Smith; Sajid Soofi; Catherine Y Spong; Shahin Sultana; Antoinette Tshefu; Frank van Bel; Lauren Vestewig Gray; Peter Waiswa; Wei Wang; Sarah LA Williams; Linda Wright; Anita Zaidi; Yanfeng Zhang; Nanbert Zhong; Isabel Zuniga; Rajiv Bahl

doi:10.7189/jogh.06.010508

Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

Sachiyo Yoshida, José Martines, Joy E Lawn, Stephen Wall, Joăo Paulo Souza, Igor Rudan, Simon Cousens, Peter Aaby, Ishag Adam, Ramesh Kant Adhikari, Namasivayam Ambalavanan, Shams Ei Arifeen, Dhana Raj Aryal, Sk Asiruddin, Abdullah Baqui, Aluisio Jd Barros, Christine S Benn, Vineet Bhandari, Shinjini Bhatnagar, Sohinee BhattacharyaZulfiqar A Bhutta, Robert E Black, Hannah Blencowe, Carl Bose, Justin Brown, Christoph Bührer, Wally Carlo, Jose Guilherme Cecatti, Po-Yin Cheung, Robert Clark, Tim Colbourn, Agustin Conde-Agudelo, Erica Corbett, Andrew E Czeizel, Abhik Das, Louise Tina Day, Carolyn Deal, Ashok Deorari, Uğur Dilmen, Mike English, Cyril Engmann, Fabian Esamai, Caroline Fall, Donna M Ferriero, Peter Gisore, Tabish Hazir, Rosemary D Higgins, Caroline Se Homer, D E Hoque, Lorentz Irgens, M T Islam, Joseph de Graft-Johnson, Martias Alice Joshua, William Keenan, Soofia Khatoon, Helle Kieler, Michael S Kramer, Eve M Lackritz, Tina Lavender, Laurensia Lawintono, Richard Luhanga, David Marsh, Douglas McMillan, Patrick J McNamara, Ben Willem J Mol, Elizabeth Molyneux, G K Mukasa, Miriam Mutabazi, Luis Carlos Nacul, Margaret Nakakeeto, Indira Narayanan, Bolajoko Olusanya, David Osrin, Vinod Paul, Christian Poets, Uma M Reddy, Mathuram Santosham, Rubayet Sayed, Natalia E Schlabritz-Loutsevitch, Nalini Singhal, Mary Alice Smith, Peter G Smith, Sajid Soofi, Catherine Y Spong, Shahin Sultana, Antoinette Tshefu, Frank van Bel, Lauren Vestewig Gray, Peter Waiswa, Wei Wang, Sarah LA Williams, Linda Wright, Anita Zaidi, Yanfeng Zhang, Nanbert Zhong, Isabel Zuniga, Rajiv Bahl

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025. METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Original language	English
Journal	Journal of global health
Volume	6
Issue number	1
Early online date	30 Aug 2015
DOIs	https://doi.org/10.7189/jogh.06.010508
Publication status	Published - Jun 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7189/jogh.06.010508

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Yoshida, S., Martines, J., Lawn, J. E., Wall, S., Souza, J. P., Rudan, I., Cousens, S., Aaby, P., Adam, I., Adhikari, R. K., Ambalavanan, N., Arifeen, S. E., Aryal, D. R., Asiruddin, S., Baqui, A., Barros, A. J., Benn, C. S., Bhandari, V., Bhatnagar, S., ... Bahl, R. (2016). Setting research priorities to improve global newborn health and prevent stillbirths by 2025. Journal of global health, 6(1). https://doi.org/10.7189/jogh.06.010508

@article{91a009d06eef4f65a60d6ec9563596a1,

title = "Setting research priorities to improve global newborn health and prevent stillbirths by 2025.",

abstract = "BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025. METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.",

author = "Sachiyo Yoshida and Jos{\'e} Martines and Lawn, {Joy E} and Stephen Wall and Souza, {Jo{\u a}o Paulo} and Igor Rudan and Simon Cousens and Peter Aaby and Ishag Adam and Adhikari, {Ramesh Kant} and Namasivayam Ambalavanan and Arifeen, {Shams Ei} and Aryal, {Dhana Raj} and Sk Asiruddin and Abdullah Baqui and Barros, {Aluisio Jd} and Benn, {Christine S} and Vineet Bhandari and Shinjini Bhatnagar and Sohinee Bhattacharya and Bhutta, {Zulfiqar A} and Black, {Robert E} and Hannah Blencowe and Carl Bose and Justin Brown and Christoph B{\"u}hrer and Wally Carlo and Cecatti, {Jose Guilherme} and Po-Yin Cheung and Robert Clark and Tim Colbourn and Agustin Conde-Agudelo and Erica Corbett and Czeizel, {Andrew E} and Abhik Das and Day, {Louise Tina} and Carolyn Deal and Ashok Deorari and Uğur Dilmen and Mike English and Cyril Engmann and Fabian Esamai and Caroline Fall and Ferriero, {Donna M} and Peter Gisore and Tabish Hazir and Higgins, {Rosemary D} and Homer, {Caroline Se} and Hoque, {D E} and Lorentz Irgens and Islam, {M T} and {de Graft-Johnson}, Joseph and Joshua, {Martias Alice} and William Keenan and Soofia Khatoon and Helle Kieler and Kramer, {Michael S} and Lackritz, {Eve M} and Tina Lavender and Laurensia Lawintono and Richard Luhanga and David Marsh and Douglas McMillan and McNamara, {Patrick J} and Mol, {Ben Willem J} and Elizabeth Molyneux and Mukasa, {G K} and Miriam Mutabazi and Nacul, {Luis Carlos} and Margaret Nakakeeto and Indira Narayanan and Bolajoko Olusanya and David Osrin and Vinod Paul and Christian Poets and Reddy, {Uma M} and Mathuram Santosham and Rubayet Sayed and Schlabritz-Loutsevitch, {Natalia E} and Nalini Singhal and Smith, {Mary Alice} and Smith, {Peter G} and Sajid Soofi and Spong, {Catherine Y} and Shahin Sultana and Antoinette Tshefu and {van Bel}, Frank and Gray, {Lauren Vestewig} and Peter Waiswa and Wei Wang and Williams, {Sarah LA} and Linda Wright and Anita Zaidi and Yanfeng Zhang and Nanbert Zhong and Isabel Zuniga and Rajiv Bahl",

year = "2016",

month = jun,

doi = "10.7189/jogh.06.010508",

language = "English",

volume = "6",

journal = "Journal of global health",

issn = "2047-2978",

publisher = "Edinburgh University Global Health Society",

number = "1",

}

Yoshida, S, Martines, J, Lawn, JE, Wall, S, Souza, JP, Rudan, I, Cousens, S, Aaby, P, Adam, I, Adhikari, RK, Ambalavanan, N, Arifeen, SE, Aryal, DR, Asiruddin, S, Baqui, A, Barros, AJ, Benn, CS, Bhandari, V, Bhatnagar, S, Bhattacharya, S, Bhutta, ZA, Black, RE, Blencowe, H, Bose, C, Brown, J, Bührer, C, Carlo, W, Cecatti, JG, Cheung, P-Y, Clark, R, Colbourn, T, Conde-Agudelo, A, Corbett, E, Czeizel, AE, Das, A, Day, LT, Deal, C, Deorari, A, Dilmen, U, English, M, Engmann, C, Esamai, F, Fall, C, Ferriero, DM, Gisore, P, Hazir, T, Higgins, RD, Homer, CS, Hoque, DE, Irgens, L, Islam, MT, de Graft-Johnson, J, Joshua, MA, Keenan, W, Khatoon, S, Kieler, H, Kramer, MS, Lackritz, EM, Lavender, T, Lawintono, L, Luhanga, R, Marsh, D, McMillan, D, McNamara, PJ, Mol, BWJ, Molyneux, E, Mukasa, GK, Mutabazi, M, Nacul, LC, Nakakeeto, M, Narayanan, I, Olusanya, B, Osrin, D, Paul, V, Poets, C, Reddy, UM, Santosham, M, Sayed, R, Schlabritz-Loutsevitch, NE, Singhal, N, Smith, MA, Smith, PG, Soofi, S, Spong, CY, Sultana, S, Tshefu, A, van Bel, F, Gray, LV, Waiswa, P, Wang, W, Williams, SLA, Wright, L, Zaidi, A, Zhang, Y, Zhong, N, Zuniga, I & Bahl, R 2016, 'Setting research priorities to improve global newborn health and prevent stillbirths by 2025.', Journal of global health, vol. 6, no. 1. https://doi.org/10.7189/jogh.06.010508

TY - JOUR

T1 - Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

AU - Yoshida, Sachiyo

AU - Martines, José

AU - Lawn, Joy E

AU - Wall, Stephen

AU - Souza, Joăo Paulo

AU - Rudan, Igor

AU - Cousens, Simon

AU - Aaby, Peter

AU - Adam, Ishag

AU - Adhikari, Ramesh Kant

AU - Ambalavanan, Namasivayam

AU - Arifeen, Shams Ei

AU - Aryal, Dhana Raj

AU - Asiruddin, Sk

AU - Baqui, Abdullah

AU - Barros, Aluisio Jd

AU - Benn, Christine S

AU - Bhandari, Vineet

AU - Bhatnagar, Shinjini

AU - Bhattacharya, Sohinee

AU - Bhutta, Zulfiqar A

AU - Black, Robert E

AU - Blencowe, Hannah

AU - Bose, Carl

AU - Brown, Justin

AU - Bührer, Christoph

AU - Carlo, Wally

AU - Cecatti, Jose Guilherme

AU - Cheung, Po-Yin

AU - Clark, Robert

AU - Colbourn, Tim

AU - Conde-Agudelo, Agustin

AU - Corbett, Erica

AU - Czeizel, Andrew E

AU - Das, Abhik

AU - Day, Louise Tina

AU - Deal, Carolyn

AU - Deorari, Ashok

AU - Dilmen, Uğur

AU - English, Mike

AU - Engmann, Cyril

AU - Esamai, Fabian

AU - Fall, Caroline

AU - Ferriero, Donna M

AU - Gisore, Peter

AU - Hazir, Tabish

AU - Higgins, Rosemary D

AU - Homer, Caroline Se

AU - Hoque, D E

AU - Irgens, Lorentz

AU - Islam, M T

AU - de Graft-Johnson, Joseph

AU - Joshua, Martias Alice

AU - Keenan, William

AU - Khatoon, Soofia

AU - Kieler, Helle

AU - Kramer, Michael S

AU - Lackritz, Eve M

AU - Lavender, Tina

AU - Lawintono, Laurensia

AU - Luhanga, Richard

AU - Marsh, David

AU - McMillan, Douglas

AU - McNamara, Patrick J

AU - Mol, Ben Willem J

AU - Molyneux, Elizabeth

AU - Mukasa, G K

AU - Mutabazi, Miriam

AU - Nacul, Luis Carlos

AU - Nakakeeto, Margaret

AU - Narayanan, Indira

AU - Olusanya, Bolajoko

AU - Osrin, David

AU - Paul, Vinod

AU - Poets, Christian

AU - Reddy, Uma M

AU - Santosham, Mathuram

AU - Sayed, Rubayet

AU - Schlabritz-Loutsevitch, Natalia E

AU - Singhal, Nalini

AU - Smith, Mary Alice

AU - Smith, Peter G

AU - Soofi, Sajid

AU - Spong, Catherine Y

AU - Sultana, Shahin

AU - Tshefu, Antoinette

AU - van Bel, Frank

AU - Gray, Lauren Vestewig

AU - Waiswa, Peter

AU - Wang, Wei

AU - Williams, Sarah LA

AU - Wright, Linda

AU - Zaidi, Anita

AU - Zhang, Yanfeng

AU - Zhong, Nanbert

AU - Zuniga, Isabel

AU - Bahl, Rajiv

PY - 2016/6

Y1 - 2016/6

N2 - BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025. METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

AB - BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025. METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

U2 - 10.7189/jogh.06.010508

DO - 10.7189/jogh.06.010508

M3 - Article

C2 - 26401272

SN - 2047-2978

VL - 6

JO - Journal of global health

JF - Journal of global health

IS - 1

ER -

Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

Abstract

UN SDGs

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