Abstract
The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales – from cellular to host level, to population level – has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales.
Original language | English |
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Pages (from-to) | 45-48 |
Number of pages | 4 |
Journal | Epidemics |
Volume | 10 |
DOIs | |
Publication status | Published - Mar 2015 |
Keywords
- Within-host
- Multiple scales
- Superinfection
- Transmission bottlenecks
- Deep-sequencing