Sex-different association of DAO with schizophrenia in Koreans

Kathryn Abel, Byungsu Kim, Hyunsook Kim, Yeon Ho Joo, Jiyoung Lim, Chang Yoon Kim, Kyuyoung Song

    Research output: Contribution to journalArticlepeer-review


    The gene encoding d-amino acid oxidase (DAO), which acts as a receptor for the schizophrenia-associated neurotransmitter, N-methyl-D-aspartate (NMDA), is regarded as a potential candidate gene for schizophrenia. However, the potential association of the DAO gene with schizophrenia has been the subject of some debate. Here, we tested three single nucleotide polymorphisms (SNPs) of DAO in a group of Korean schizophrenia patients, and found no significant association in the overall study subjects. Interestingly, however, we found gender-specific differences in allele distributions, with SNP rs2070586 appearing to act as a risk allele in female schizophrenia patients, but as a protective allele in males. Our data support the hypothesis that DAO plays a role in schizophrenia, possibly in a gender-dependent manner. © 2008 Elsevier Ireland Ltd.
    Original languageEnglish
    Pages (from-to)121-125
    Number of pages4
    JournalPsychiatry Research
    Issue number2
    Publication statusPublished - Sept 2010


    • Association study
    • D-amino-acid oxidase
    • Korean
    • Schizophrenia


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