Sexual activity and prostate cancer risk in men diagnosed at a younger age

Polyxeni Dimitropoulou, Artitaya Lophatananon, Douglas Easton, Richard Pocock, David P. Dearnaley, Michelle Guy, Steven Edwards, Lynne O'Brien, Amanda Hall, Rosemary Wilkinson, Rosalind Eeles, Kenneth R. Muir

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVE: To examine, in a case-control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at ≤60 years old. PATIENTS, SUBJECTS AND METHODS: In all, 431 prostate cancer cases and 409 controls participated and provided information on their sexual activity. In particular, the frequencies of intercourse and masturbation during the participants' different age decades (20s, 30s, 40s, 50s) were collected. RESULTS: Whereas frequent overall sexual activity in younger life (20s) increased the disease risk, it appeared to be protective against the disease when older (50s). Alone, frequent masturbation activity was a marker for increased risk in the 20s and 30s but appeared to be associated with a decreased risk in the 50s, while intercourse activity alone was not associated with the disease. CONCLUSION: These findings could imply different mechanisms by which sexual activity is involved in the aetiology of prostate cancer at different ages. Alternatively, there is a possibility of reverse causation in explaining part of the protective effect seen for men in their 50s. © 2008 The Authors.
    Original languageEnglish
    Pages (from-to)178-185
    Number of pages7
    JournalBJU international
    Volume103
    Issue number2
    DOIs
    Publication statusPublished - Jan 2009

    Keywords

    • Cancer risk
    • Intercourse
    • Masturbation
    • Prostate
    • Sexual activity

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