SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus

J. G. Hanly, M. B. Urowitz, D. Jackson, S. C. Bae, C. Gordon, D. J. Wallace, A. Clarke, S. Bernatsky, A. Vasudevan, D. Isenberg, A. Rahman, J. Sanchez-Guerrero, J. Romero-Diaz, J. T. Merrill, P. R. Fortin, D. D. Gladman, I. N. Bruce, K. Steinsson, M. Khamashta, G. S. AlarcónB. Fessler, M. Petri, S. Manzi, O. Nived, G. Sturfelt, R. Ramsey-Goldman, M. A. Dooley, C. Aranow, R. Van Vollenhoven, M. Ramos-Casals, A. Zoma, K. Kalunian, V. Farewell

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric eventsattributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed sevenpoint scale and compared with patient-completed ShortForm 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3±2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p
    Original languageEnglish
    Pages (from-to)961-967
    Number of pages6
    JournalAnnals of the rheumatic diseases
    Volume70
    Issue number6
    DOIs
    Publication statusPublished - Jun 2011

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