Abstract
Short, stereoselective and efficient total syntheses of the bioactive β-aryl ethanolamine derivatives (R)-tembamide, (R)-aegeline and (R)-pronethalol have been achieved using the highly diastereoselective oxy-Michael addition of 'naked' delta lactol anions to nitro olefins as the key step. © 2003 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 195-197 |
Number of pages | 2 |
Journal | Tetrahedron Asymmetry |
Volume | 15 |
Issue number | 2 |
DOIs | |
Publication status | Published - 26 Jan 2004 |
Keywords
- Asymmetric synthesis and induction (asym. synthesis of bioactive b-aryl ethanolamine derivs. via diastereoselective delta lactol oxy-Michael addn.); Michael reaction (stereoselective; asym. synthesis of bioactive b-aryl ethanolamine derivs. via diastereoselective delta lactol oxy-Michael addn.)