Abstract
The increasing antimicrobial resistance (AMR) to current antibiotics has posed a global threat to human health care and animal welfare. It is urgent to develop new antimicrobial agents and treatment processes that can help us to win the fight against AMR. Short antimicrobial peptides kill microbial pathogens mainly via rapid disruption to bacterial membranes. It is less likely for this mode of action to trigger resistance. Peptides can readily form hydrogels via self‐assembly, enzymatic triggering, or chemical cross‐linking, and their effective antimicrobial concentrations can be tuned to particular needs, thereby reducing concentration‐dependent toxicity. The peptide hydrogels formed possess fibrous structures and mimic cell extracellular matrices, and they can boost host cell growth and accelerate the wound‐healing process. At the same time, they can also entrap multiple antimicrobial …
| Original language | English |
|---|---|
| Title of host publication | Peptide Self‐Assembly and Engineering |
| Subtitle of host publication | Fundamentals, Structures, and Applications |
| Editors | Xuehai Yan |
| Publisher | John Wiley & Sons Ltd |
| Chapter | 19 |
| Pages | 449-477 |
| Number of pages | 29 |
| Volume | 2 |
| ISBN (Electronic) | 9783527841264 |
| ISBN (Print) | 9783527351916 |
| DOIs | |
| Publication status | Published - 2 Feb 2024 |