Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

Jorgen Vestbo; Line Rode; Stig E. Bojesen; Maren Weischer; Jørgen Vestbo; Børge G. Nordestgaard

doi:10.1136/thoraxjnl-2012-202544

Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

Jorgen Vestbo, Line Rode, Stig E. Bojesen, Maren Weischer, Jørgen Vestbo, Børge G. Nordestgaard

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio

Original language	English
Pages (from-to)	429-435
Number of pages	6
Journal	Thorax
Volume	68
Issue number	5
DOIs	https://doi.org/10.1136/thoraxjnl-2012-202544
Publication status	Published - May 2013

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10.1136/thoraxjnl-2012-202544

http://thorax.bmj.com/content/68/5/429.full.pdf

Cite this

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title = "Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals",

abstract = "Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio",

author = "Jorgen Vestbo and Line Rode and Bojesen, {Stig E.} and Maren Weischer and J{\o}rgen Vestbo and Nordestgaard, {B{\o}rge G.}",

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AU - Vestbo, Jorgen

AU - Rode, Line

AU - Bojesen, Stig E.

AU - Weischer, Maren

AU - Vestbo, Jørgen

AU - Nordestgaard, Børge G.

PY - 2013/5

Y1 - 2013/5

N2 - Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio

AB - Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio

U2 - 10.1136/thoraxjnl-2012-202544

DO - 10.1136/thoraxjnl-2012-202544

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SN - 0040-6376

VL - 68

SP - 429

EP - 435

JO - Thorax

JF - Thorax

IS - 5

ER -

Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

Abstract

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