Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

Jorgen Vestbo; Line Rode; Stig E. Bojesen; Maren Weischer; Jørgen Vestbo; Børge G. Nordestgaard

doi:10.1136/thoraxjnl-2012-202544

Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

Jorgen Vestbo
, Line Rode
, Stig E. Bojesen
, Maren Weischer
, Jørgen Vestbo
, Børge G. Nordestgaard

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio

Original language	English
Pages (from-to)	429-435
Number of pages	6
Journal	Thorax
Volume	68
Issue number	5
DOIs	https://doi.org/10.1136/thoraxjnl-2012-202544
Publication status	Published - May 2013

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10.1136/thoraxjnl-2012-202544

http://thorax.bmj.com/content/68/5/429.full.pdf

Cite this

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title = "Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals",

abstract = "Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio",

author = "Jorgen Vestbo and Line Rode and Bojesen, \{Stig E.\} and Maren Weischer and J{\o}rgen Vestbo and Nordestgaard, \{B{\o}rge G.\}",

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T1 - Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

AU - Vestbo, Jorgen

AU - Rode, Line

AU - Bojesen, Stig E.

AU - Weischer, Maren

AU - Vestbo, Jørgen

AU - Nordestgaard, Børge G.

PY - 2013/5

Y1 - 2013/5

N2 - Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio

AB - Background: A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD). Objectives: To test the hypothesis that short telomere length is associated with reduced lung function and an increased risk of COPD. Methods: Observational study of 46 396 individuals from the Danish general population. Measurements: Leucocyte telomere length and spirometry were measured. COPD was defined using either fixed forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio

U2 - 10.1136/thoraxjnl-2012-202544

DO - 10.1136/thoraxjnl-2012-202544

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SN - 0040-6376

VL - 68

SP - 429

EP - 435

JO - Thorax

JF - Thorax

IS - 5

ER -

Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

Abstract

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