Sialic acids in infection and their potential use in detection and protection against pathogens

Simone Dedola; Sanaz Ahmadipour; Peterson de Andrade; Alexander N. Baker; Andrew N. Boshra; Simona Chessa; Matthew I. Gibson; Pedro J. Hernando; Irina M. Ivanova; Jessica E. Lloyd; María J. Marín; Alexandra J. Munro-Clark; Giulia Pergolizzi; Sarah-Jane Richards; Iakovia Ttofi; Ben A. Wagstaff; Robert A. Field

doi:10.1039/d3cb00155e

Sialic acids in infection and their potential use in detection and protection against pathogens

Simone Dedola, Sanaz Ahmadipour, Peterson de Andrade, Alexander N. Baker, Andrew N. Boshra, Simona Chessa, Matthew I. Gibson, Pedro J. Hernando, Irina M. Ivanova, Jessica E. Lloyd, María J. Marín, Alexandra J. Munro-Clark, Giulia Pergolizzi, Sarah-Jane Richards, Iakovia Ttofi, Ben A. Wagstaff, Robert A. Field

Research output: Contribution to journal › Review article › peer-review

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Abstract

In structural terms, the sialic acids are a large family of nine carbon sugars based around an alpha-keto acid core. They are widely spread in nature, where they are often found to be involved in molecular recognition processes, including in development, immunology, health and disease. The prominence of sialic acids in infection is a result of their exposure at the non-reducing terminus of glycans in diverse glycolipids and glycoproteins. Herein, we survey representative aspects of sialic acid structure, recognition and exploitation in relation to infectious diseases, their diagnosis and prevention or treatment. Examples covered span influenza virus and Covid-19, Leishmania and Trypanosoma, algal viruses, Campylobacter, Streptococci and Helicobacter, and commensal Ruminococci.

Original language	English
Pages (from-to)	167-188
Number of pages	22
Journal	RSC Chemical Biology
Volume	5
Issue number	3
Early online date	19 Dec 2023
DOIs	https://doi.org/10.1039/d3cb00155e
Publication status	Published - 1 Mar 2024

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Dedola, S., Ahmadipour, S., Andrade, P. D., Baker, A. N., Boshra, A. N., Chessa, S., Gibson, M. I., Hernando, P. J., Ivanova, I. M., Lloyd, J. E., Marín, M. J., Munro-Clark, A. J., Pergolizzi, G., Richards, S.-J., Ttofi, I., Wagstaff, B. A., & Field, R. A. (2024). Sialic acids in infection and their potential use in detection and protection against pathogens. RSC Chemical Biology, 5(3), 167-188. https://doi.org/10.1039/d3cb00155e

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title = "Sialic acids in infection and their potential use in detection and protection against pathogens",

abstract = "In structural terms, the sialic acids are a large family of nine carbon sugars based around an alpha-keto acid core. They are widely spread in nature, where they are often found to be involved in molecular recognition processes, including in development, immunology, health and disease. The prominence of sialic acids in infection is a result of their exposure at the non-reducing terminus of glycans in diverse glycolipids and glycoproteins. Herein, we survey representative aspects of sialic acid structure, recognition and exploitation in relation to infectious diseases, their diagnosis and prevention or treatment. Examples covered span influenza virus and Covid-19, Leishmania and Trypanosoma, algal viruses, Campylobacter, Streptococci and Helicobacter, and commensal Ruminococci.",

author = "Simone Dedola and Sanaz Ahmadipour and Andrade, {Peterson de} and Baker, {Alexander N.} and Boshra, {Andrew N.} and Simona Chessa and Gibson, {Matthew I.} and Hernando, {Pedro J.} and Ivanova, {Irina M.} and Lloyd, {Jessica E.} and Mar{\'i}n, {Mar{\'i}a J.} and Munro-Clark, {Alexandra J.} and Giulia Pergolizzi and Sarah-Jane Richards and Iakovia Ttofi and Wagstaff, {Ben A.} and Field, {Robert A.}",

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doi = "10.1039/d3cb00155e",

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Dedola, S, Ahmadipour, S, Andrade, PD, Baker, AN, Boshra, AN, Chessa, S, Gibson, MI, Hernando, PJ, Ivanova, IM, Lloyd, JE, Marín, MJ, Munro-Clark, AJ, Pergolizzi, G, Richards, S-J, Ttofi, I, Wagstaff, BA & Field, RA 2024, 'Sialic acids in infection and their potential use in detection and protection against pathogens', RSC Chemical Biology, vol. 5, no. 3, pp. 167-188. https://doi.org/10.1039/d3cb00155e

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T1 - Sialic acids in infection and their potential use in detection and protection against pathogens

AU - Dedola, Simone

AU - Ahmadipour, Sanaz

AU - Andrade, Peterson de

AU - Baker, Alexander N.

AU - Boshra, Andrew N.

AU - Chessa, Simona

AU - Gibson, Matthew I.

AU - Hernando, Pedro J.

AU - Ivanova, Irina M.

AU - Lloyd, Jessica E.

AU - Marín, María J.

AU - Munro-Clark, Alexandra J.

AU - Pergolizzi, Giulia

AU - Richards, Sarah-Jane

AU - Ttofi, Iakovia

AU - Wagstaff, Ben A.

AU - Field, Robert A.

PY - 2024/3/1

Y1 - 2024/3/1

N2 - In structural terms, the sialic acids are a large family of nine carbon sugars based around an alpha-keto acid core. They are widely spread in nature, where they are often found to be involved in molecular recognition processes, including in development, immunology, health and disease. The prominence of sialic acids in infection is a result of their exposure at the non-reducing terminus of glycans in diverse glycolipids and glycoproteins. Herein, we survey representative aspects of sialic acid structure, recognition and exploitation in relation to infectious diseases, their diagnosis and prevention or treatment. Examples covered span influenza virus and Covid-19, Leishmania and Trypanosoma, algal viruses, Campylobacter, Streptococci and Helicobacter, and commensal Ruminococci.

AB - In structural terms, the sialic acids are a large family of nine carbon sugars based around an alpha-keto acid core. They are widely spread in nature, where they are often found to be involved in molecular recognition processes, including in development, immunology, health and disease. The prominence of sialic acids in infection is a result of their exposure at the non-reducing terminus of glycans in diverse glycolipids and glycoproteins. Herein, we survey representative aspects of sialic acid structure, recognition and exploitation in relation to infectious diseases, their diagnosis and prevention or treatment. Examples covered span influenza virus and Covid-19, Leishmania and Trypanosoma, algal viruses, Campylobacter, Streptococci and Helicobacter, and commensal Ruminococci.

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EP - 188

JO - RSC Chemical Biology

JF - RSC Chemical Biology

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ER -

Sialic acids in infection and their potential use in detection and protection against pathogens

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