Signal recognition particles in chloroplasts, bacteria, yeast and mammals

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The Signal Recognition Particle (SRP) plays a critical role in the sorting of nascent secretory and membrane proteins. Remarkably, this function has been conserved from bacteria, where SRP delivers proteins to the inner membrane, through to eukaryotes, where SRP is required for targeting of proteins to the endoplasmic reticulum. This review focuses on present understanding of SRP structure and function and the relationship between the two. Furthermore, the similarities and differences in the structure, function and cellular role of SRP in bacteria, chloroplasts, fungi and mammals will be stressed. © 2005 Taylor & Francis.
    Original languageEnglish
    Pages (from-to)3-15
    Number of pages12
    JournalMolecular Membrane Biology
    Volume22
    Issue number1-2
    DOIs
    Publication statusPublished - Jan 2005

    Keywords

    • GTPase
    • Ribosome
    • Signal recognition particle
    • Structure/function
    • Targeting

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