Signaling Pathway of β-Adrenergic Receptor in Astrocytes and its Relevance to Brain Edema

Baoman Li, Dan Song, Ting Du, Alexei Verkhratsky, Liang Peng

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Astroglia express β1- and β2-adrenergic receptors. Stimulation of astrocytic β1-adreneergic receptors inducs extracllular regulated kinase 1 and 2 (ERK1/2) phosphorylation via protein kinase A, Gs/Gi switching, Ca2+ release from intracllular stores, metalloproteinase-catalyzed release of growth factor, and transactivation of epidermal growth factor receptor; while stimulation of β2-adrenergic receptors inducs ERK1/2 phosphorylation by β-arrestin-mediated Src activation, without the involvement of epidermal growth factor receptor activation. Brain edema after 3h of focal ischemia followed by 8h reperfusion can be prevented by antagonists of β1-adrenergic receptor and inhibitors of the associated signaling pathway, whereas inhibition of β2-adrenergic cascade has no effect. In astrocytes in primary cultures, stimulation of β1-adrenergic receptor increases the activity of both Na,K-ATPase and Na-K-Cl cotransporter NKCC1. Here we discuss mechanisms underlying the effects of β1-adrenergic receptor activation on brain edema, with particular emphasis on the signaling pathway of β1-adrenergic receptor, extracllular ions and mitogen-activated protein kinase/ERK1/2 cascade during ischemia and reperfusion periods.

Original languageEnglish
Title of host publicationNoradrenergic Signaling and Astroglia
EditorsNina Vardjan, Robert Zorec
PublisherElsevier BV
Chapter13
Pages257-271
Number of pages15
ISBN (Electronic)9780128134269
ISBN (Print)9780128050880
DOIs
Publication statusPublished - 21 Jul 2017

Keywords

  • Astrocyte
  • Brain edema
  • EGF receptor
  • MAPK/ERK pathway
  • Na,K-ATPase
  • NKCC1
  • β-adrenergic receptor

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