Abstract
Interactions with an appropriate ECM are crucial for normal cell behaviour. The basement membrane contributes to both the tissue-specific lactational function and survival of mammary epithelial cells, possibly through a similar β1-integrin-dependent mechanism. Of current interest is whether the downstream intracellular signals diverge, with milk expression regulated through cell shape and the Jak-Stat pathway and survival mediated through controls on the Bcl-2/Bax and Ice checkpoints.
| Original language | English |
|---|---|
| Pages (from-to) | 464-468 |
| Number of pages | 4 |
| Journal | Biochemical Society Transactions |
| Volume | 23 |
| Issue number | 3 |
| Publication status | Published - 1995 |
Keywords
- Animals
- Basement Membrane/physiology
- Cell Differentiation
- Cell Survival
- Epithelial Cells
- Extracellular Matrix/*physiology
- Female
- In Vitro
- Mammary Glands, Animal/*cytology/growth & development/physiology
- Mice
- Phenotype
- Pregnancy
- Signal Transduction/*physiology
- Support, Non-U.S. Gov't