Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds

Michael J. James, James D. Cuthbertson, Peter O'brien, Richard J. K. Taylor, William P. Unsworth

Research output: Contribution to journalArticlepeer-review

Abstract

A high-yielding silver(I)- or copper(II)-catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain ynone substituents, including indole, anisole, pyrrole, and benzofuran derivatives, into functionalized spirocyclic scaffolds. A high-yielding asymmetric variant furnishes spirocyclic indolenines in up to 89:11 e.r.
Original languageEnglish
Pages (from-to)7640-7643
Number of pages4
JournalAngewandte Chemie International Edition
Volume54
Issue number26
DOIs
Publication statusPublished - 22 Jun 2015

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