Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

Michael R. Chapman; Maria H.T. Kwan; Georgina King; Katherine E. Jolley; Mariam Hussain; Shahed Hussain; Ibrahim E. Salama; Carlos González Nino; Lisa A. Thompson; Mary E. Bayana; Adam D. Clayton; Bao N. Nguyen; Nicholas J. Turner; Nikil Kapur; A. John Blacker

doi:10.1021/acs.oprd.7b00173

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

Michael R. Chapman, Maria H.T. Kwan, Georgina King, Katherine E. Jolley, Mariam Hussain, Shahed Hussain, Ibrahim E. Salama, Carlos González Nino, Lisa A. Thompson, Mary E. Bayana, Adam D. Clayton, Bao N. Nguyen, Nicholas J. Turner, Nikil Kapur^*, A. John Blacker

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A universal multistage cascade CSTR has been developed that is suitable for a wide range of continuous-flow processes. Coined by our group the "Freactor" (free-to-access reactor), the new reactor integrates the efficiency of pipe-flow processing with the advanced mixing of a CSTR, delivering a general "plug-and-play" reactor platform which is well-suited to multiphasic continuous-flow chemistry. Importantly, the reactor geometry is easily customized to accommodate reactions requiring long residence times (≥3 h tested).

Original language	English
Pages (from-to)	1294-1301
Number of pages	8
Journal	Organic Process Research and Development
Volume	21
Issue number	9
Early online date	28 Jun 2017
DOIs	https://doi.org/10.1021/acs.oprd.7b00173
Publication status	Published - 15 Sept 2017

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Manchester Institute of Biotechnology

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Chapman, M. R., Kwan, M. H. T., King, G., Jolley, K. E., Hussain, M., Hussain, S., Salama, I. E., González Nino, C., Thompson, L. A., Bayana, M. E., Clayton, A. D., Nguyen, B. N., Turner, N. J., Kapur, N., & Blacker, A. J. (2017). Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times. Organic Process Research and Development, 21(9), 1294-1301. https://doi.org/10.1021/acs.oprd.7b00173

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abstract = "A universal multistage cascade CSTR has been developed that is suitable for a wide range of continuous-flow processes. Coined by our group the {"}Freactor{"} (free-to-access reactor), the new reactor integrates the efficiency of pipe-flow processing with the advanced mixing of a CSTR, delivering a general {"}plug-and-play{"} reactor platform which is well-suited to multiphasic continuous-flow chemistry. Importantly, the reactor geometry is easily customized to accommodate reactions requiring long residence times (≥3 h tested).",

author = "Chapman, {Michael R.} and Kwan, {Maria H.T.} and Georgina King and Jolley, {Katherine E.} and Mariam Hussain and Shahed Hussain and Salama, {Ibrahim E.} and {Gonz{\'a}lez Nino}, Carlos and Thompson, {Lisa A.} and Bayana, {Mary E.} and Clayton, {Adam D.} and Nguyen, {Bao N.} and Turner, {Nicholas J.} and Nikil Kapur and Blacker, {A. John}",

year = "2017",

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day = "15",

doi = "10.1021/acs.oprd.7b00173",

language = "English",

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Chapman, MR, Kwan, MHT, King, G, Jolley, KE, Hussain, M, Hussain, S, Salama, IE, González Nino, C, Thompson, LA, Bayana, ME, Clayton, AD, Nguyen, BN, Turner, NJ, Kapur, N & Blacker, AJ 2017, 'Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times', Organic Process Research and Development, vol. 21, no. 9, pp. 1294-1301. https://doi.org/10.1021/acs.oprd.7b00173

TY - JOUR

T1 - Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

AU - Chapman, Michael R.

AU - Kwan, Maria H.T.

AU - King, Georgina

AU - Jolley, Katherine E.

AU - Hussain, Mariam

AU - Hussain, Shahed

AU - Salama, Ibrahim E.

AU - González Nino, Carlos

AU - Thompson, Lisa A.

AU - Bayana, Mary E.

AU - Clayton, Adam D.

AU - Nguyen, Bao N.

AU - Turner, Nicholas J.

AU - Kapur, Nikil

AU - Blacker, A. John

PY - 2017/9/15

Y1 - 2017/9/15

N2 - A universal multistage cascade CSTR has been developed that is suitable for a wide range of continuous-flow processes. Coined by our group the "Freactor" (free-to-access reactor), the new reactor integrates the efficiency of pipe-flow processing with the advanced mixing of a CSTR, delivering a general "plug-and-play" reactor platform which is well-suited to multiphasic continuous-flow chemistry. Importantly, the reactor geometry is easily customized to accommodate reactions requiring long residence times (≥3 h tested).

AB - A universal multistage cascade CSTR has been developed that is suitable for a wide range of continuous-flow processes. Coined by our group the "Freactor" (free-to-access reactor), the new reactor integrates the efficiency of pipe-flow processing with the advanced mixing of a CSTR, delivering a general "plug-and-play" reactor platform which is well-suited to multiphasic continuous-flow chemistry. Importantly, the reactor geometry is easily customized to accommodate reactions requiring long residence times (≥3 h tested).

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SP - 1294

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JO - Organic Process Research and Development

JF - Organic Process Research and Development

IS - 9

ER -

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

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