The 1H NMR analysis of species containing NMR-active heteronuclei can be difficult due to signal overlap caused by the combined effects of homonuclear and heteronuclear scalar (J) couplings. Here, a general pure shift method is presented for obtaining ultra-high resolution 1H NMR spectra where spectral overlap is drastically reduced by suppressing both homonuclear and heteronuclear J-couplings, giving one single signal per 1H chemical environment. Its usefulness is demonstrated in the analysis of fluorine- and phosphorus-containing compounds of pharmaceutical and biochemical interest.
|Early online date||22 Aug 2022|
|Publication status||Published - 22 Aug 2022|
- Analytical methods
- NMR spectroscopy
- Structure elucidation
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Simultaneous broadband suppression of homonuclear and heteronuclear couplings in 1H NMR spectroscopy
Castanar Acedo, L. (Creator), Morris, G. (Creator), Nilsson, M. (Creator) & Mycroft, C. (Creator), University of Manchester Figshare, 17 May 2022
DOI: 10.48420/19583323.v1, https://figshare.manchester.ac.uk/articles/dataset/Simultaneous_broadband_suppression_of_homonuclear_and_heteronuclear_couplings_in_1H_NMR_spectroscopy/19583323/1