Single cells get together: High-resolution approaches to study the dynamics of early mouse development.

Néstor Saiz; Berenika Plusa; Anna-Katerina Hadjantonakis

doi:10.1016/j.semcdb.2015.06.004

Single cells get together: High-resolution approaches to study the dynamics of early mouse development.

Néstor Saiz
, Berenika Plusa
, Anna-Katerina Hadjantonakis

Research output: Contribution to journal › Article › peer-review

Abstract

Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are making it possible to study cellular populations at single-cell resolution and begin to integrate different inputs, for example genetic, physical and chemical factors, that affect cell differentiation over spatial and temporal scales. The preimplantation mouse embryo allows the analysis of cell fate decisions in vivo with high spatiotemporal resolution. In this review we highlight how the application of live imaging and single-cell resolution analysis pipelines is providing an unprecedented level of insight on the processes that shape the earliest stages of mammalian development.

Original language	English
Journal	Seminars in cell & developmental biology
DOIs	https://doi.org/10.1016/j.semcdb.2015.06.004
Publication status	Published - 13 Jul 2015

Keywords

Genomics
Lineage specification
Mouse embryo
Quantitative high-resolution imaging
Single-cell analysis
Systems biology

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10.1016/j.semcdb.2015.06.004

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title = "Single cells get together: High-resolution approaches to study the dynamics of early mouse development.",

abstract = "Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are making it possible to study cellular populations at single-cell resolution and begin to integrate different inputs, for example genetic, physical and chemical factors, that affect cell differentiation over spatial and temporal scales. The preimplantation mouse embryo allows the analysis of cell fate decisions in vivo with high spatiotemporal resolution. In this review we highlight how the application of live imaging and single-cell resolution analysis pipelines is providing an unprecedented level of insight on the processes that shape the earliest stages of mammalian development.",

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author = "N{\'e}stor Saiz and Berenika Plusa and Anna-Katerina Hadjantonakis",

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AU - Saiz, Néstor

AU - Plusa, Berenika

AU - Hadjantonakis, Anna-Katerina

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KW - Genomics

KW - Lineage specification

KW - Mouse embryo

KW - Quantitative high-resolution imaging

KW - Single-cell analysis

KW - Systems biology

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JF - Seminars in cell & developmental biology

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Single cells get together: High-resolution approaches to study the dynamics of early mouse development.

Abstract

Keywords

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