Single photon emission computed tomography dual isotope myocardial perfusion imaging in women with systemic lupus erythematosus. II. Predictive factors for perfusion abnormalities

Ian N. Bruce, Dafna D. Gladman, Dominique Ibañez, Murray B. Urowitz

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective. We have reported that 40% of patients with systemic lupus erythematosus (SLE) had abnormal myocardial perfusion studies. Here we investigated risk factors for abnormal myocardial perfusion in a cohort of women with SLE without history of coronary artery disease. Methods. Consecutive women with SLE followed at a large lupus clinic underwent single photon emission computed tomography dual isotope myocardial perfusion imaging (DIMPI) following pharmacological stress using dipyridamole. At the time of study each patient had a clinical and laboratory assessment performed by a standard protocol. We compared traditional risk factors as well as disease and therapy related factors in those with and without perfusion abnormalities. Results. A total of 129 patients were studied. The mean ± SD age was 44.8 ± 10.9 yrs, and mean SLE Disease Activity Index was 4.2 ± 5.1. Forty-nine (38%) patients had an abnormality of myocardial perfusion. Factors associated with an abnormal DIMPI included current hypertension (OR 2.11, p = 0.05), elevated cholesterol ever (OR 2.51, p <0.05), and total cholesterol: high density lipoprotein-cholesterol ratio (OR 1.96 for each increase of 1.0, p <0.008). Conclusion. Myocardial perfusion abnormalities are common in women with SLE without known coronary artery disease (CAD), suggesting a high burden of subclinical CAD. Several metabolic and therapy related factors appear to be associated with the process of atherogenesis in SLE. These results suggest that SLE should be considered a predisposing factor for atherosclerosis.
    Original languageEnglish
    Pages (from-to)288-291
    Number of pages3
    JournalJournal of Rheumatology
    Volume30
    Issue number2
    Publication statusPublished - 1 Feb 2003

    Keywords

    • Lupus
    • Myocardial perfusion imaging
    • Predictive factors

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