Single-scan Ultra-selective 1D Total Correlation Spectroscopy

Peter Kiraly; Mathias Nilsson; Gareth Morris; Ralph Adams

doi:10.1039/d0cc08033k

Single-scan Ultra-selective 1D Total Correlation Spectroscopy

Peter Kiraly, Mathias Nilsson, Gareth Morris, Ralph Adams

Analytical, Measurements and Physical Chemistry

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Abstract

Selective 1D TOCSY is a powerful tool in the assignment of NMR spectra of organic molecules. Here an order of magnitude improvement in selectivity, allowing overlapping multiplets to be excited separately, is achieved in a single scan using the very recent GEMSTONE method. The new experiment is illustrated using an antibiotic and a mixture of diastereomers.

Original language	English
Pages (from-to)	2368-2371
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	19
DOIs	https://doi.org/10.1039/d0cc08033k
Publication status	Published - 7 Mar 2021

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10.1039/d0cc08033k

GEMSTONE-TOCSY_2021-01-19_R2Accepted author manuscript, 3.57 MB

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title = "Single-scan Ultra-selective 1D Total Correlation Spectroscopy",

abstract = "Selective 1D TOCSY is a powerful tool in the assignment of NMR spectra of organic molecules. Here an order of magnitude improvement in selectivity, allowing overlapping multiplets to be excited separately, is achieved in a single scan using the very recent GEMSTONE method. The new experiment is illustrated using an antibiotic and a mixture of diastereomers.",

author = "Peter Kiraly and Mathias Nilsson and Gareth Morris and Ralph Adams",

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AU - Kiraly, Peter

AU - Nilsson, Mathias

AU - Morris, Gareth

AU - Adams, Ralph

N1 - Funding Information: This research was supported by the Engineering and Physical Sciences Research Council (grant numbers EP/N033949/1 and EP/R121851/1). Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/3/7

Y1 - 2021/3/7

N2 - Selective 1D TOCSY is a powerful tool in the assignment of NMR spectra of organic molecules. Here an order of magnitude improvement in selectivity, allowing overlapping multiplets to be excited separately, is achieved in a single scan using the very recent GEMSTONE method. The new experiment is illustrated using an antibiotic and a mixture of diastereomers.

AB - Selective 1D TOCSY is a powerful tool in the assignment of NMR spectra of organic molecules. Here an order of magnitude improvement in selectivity, allowing overlapping multiplets to be excited separately, is achieved in a single scan using the very recent GEMSTONE method. The new experiment is illustrated using an antibiotic and a mixture of diastereomers.

U2 - 10.1039/d0cc08033k

DO - 10.1039/d0cc08033k

M3 - Article

SN - 1359-7345

VL - 57

SP - 2368

EP - 2371

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

Single-scan Ultra-selective 1D Total Correlation Spectroscopy

Abstract

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