Single-session vs multiple-session pattern scanning laser panretinal photocoagulation in proliferative diabetic retinopathy: The Manchester Pascal study

Mahiul M K Muqit, George R. Marcellino, David B. Henson, Lorna B. Young, Niall Patton, Stephen J. Charles, George S. Turner, Paulo E. Stanga

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: To investigate the effects of pattern scanning laser (Pascal; OptiMedica, Santa Clara, California) multispot panretinal photocoagulation given in a single-session (SS-PRP) vs single-spot multiple-session PRP (MS-PRP) on proliferative diabetic retinopathy (PDR). Methods: Single-center, randomized clinical trial of 40 eyes. Proliferative diabetic retinopathy was treated with a 400-μm spot size in 1500 burns given either as Pascal in 20-millisecond SS-PRP or in 3 sessions (100-millisecond MS-PRP) during a 4-week period. Visual acuity, central subfield retinal thickness (CRT), and 24-2 Swedish interactive thresholding algorithm visual fields were recorded at baseline and 4 and 12 weeks. Main Outcome Measures: Central subfield retinal thickness, mean deviation, and PDR grade at 12 weeks. Results: There was a significant increase in mean CRT with MS-PRP (22 μm at 4 weeks, 95% CI, -32.25 to -10.75; 20 μm at 12 weeks, 95% CI, -28.75 to -10.82; P
    Original languageEnglish
    Pages (from-to)525-533
    Number of pages8
    JournalArchives of Ophthalmology
    Volume128
    Issue number5
    DOIs
    Publication statusPublished - May 2010

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