Site-isolated base- and acid-mediated Michael-initiated cyclization cascades

Adam W. Pilling, Jutta Boehmer, Darren J. Dixon

    Research output: Contribution to journalArticlepeer-review

    Abstract

    (Chemical Equation Presented) One thing leads to another: Site-isolated base and acid catalysts have been exploited in Michael addition, N-acyl iminium ion cyclization cascades with amide pronucleophiles and α,β- unsaturated carbonyl compounds. The reaction sequence has broad scope, uses commercially available catalysts, is atom efficient, and can be scaled by way of a flow-reactor setup. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)5428-5430
    Number of pages2
    JournalAngewandte Chemie - International Edition
    Volume46
    Issue number28
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Cascade reactions
    • Cyclization
    • Iminium ions
    • Michael addition

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