Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

M. Kamalov; P. W R Harris; Garth Cooper; M. A. Brimble

doi:10.1039/c4cc02003k

Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

M. Kamalov, P. W R Harris, Garth Cooper, M. A. Brimble

University of Auckland

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Abstract

Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism. © 2014 the Partner Organisations.

Original language	English
Pages (from-to)	4944-4946
Number of pages	2
Journal	Chemical Communications
Volume	50
Issue number	38
DOIs	https://doi.org/10.1039/c4cc02003k
Publication status	Published - 18 May 2014

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title = "Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts",

abstract = "Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism. {\textcopyright} 2014 the Partner Organisations.",

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AU - Kamalov, M.

AU - Harris, P. W R

AU - Cooper, Garth

AU - Brimble, M. A.

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AB - Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism. © 2014 the Partner Organisations.

U2 - 10.1039/c4cc02003k

DO - 10.1039/c4cc02003k

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VL - 50

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JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

Abstract

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