Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization

Jorgen Vestbo; Michael I. Polkey; Martijn A. Spruit; Lisa D. Edwards; Michael L. Watkins; Victor Pinto-Plata; Jørgen Vestbo; Peter M A Calverley; Ruth Tal-Singer; Alvar Agustí; Per S. Bakke; Harvey O. Coxson; David A. Lomas; William MacNee; Stephen Rennard; Edwin K. Silverman; Bruce E. Miller; Courtney Crim; Julie Yates; Emiel F M Wouters; Bartolome Celli

doi:10.1164/rccm.201209-1596OC

Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization

Jorgen Vestbo, Michael I. Polkey, Martijn A. Spruit, Lisa D. Edwards, Michael L. Watkins, Victor Pinto-Plata, Jørgen Vestbo, Peter M A Calverley, Ruth Tal-Singer, Alvar Agustí, Per S. Bakke, Harvey O. Coxson, David A. Lomas, William MacNee, Stephen Rennard, Edwin K. Silverman, Bruce E. Miller, Courtney Crim, Julie Yates, Emiel F M WoutersBartolome Celli

Research output: Contribution to journal › Article › peer-review

Abstract

Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention. Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods:Data fromtheECLIPSEcohortwereused(n=2,112).Death or first hospitalizationwere indexevents;wemeasured change in6MWDin the 12-month period before the event and related change in 6MWD to lungfunctionandSt. George'sRespiratoryQuestionnaire (healthstatus). Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P

Original language	English
Pages (from-to)	382-386
Number of pages	4
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	187
Issue number	4
DOIs	https://doi.org/10.1164/rccm.201209-1596OC
Publication status	Published - 15 Feb 2013

Keywords

6MW
COPD
Death
Hospitalization
MCID

Access to Document

10.1164/rccm.201209-1596OC

http://ajrccm.atsjournals.org/content/187/4/382.full.pdf+html

Cite this

Vestbo, J., Polkey, M. I., Spruit, M. A., Edwards, L. D., Watkins, M. L., Pinto-Plata, V., Vestbo, J., Calverley, P. M. A., Tal-Singer, R., Agustí, A., Bakke, P. S., Coxson, H. O., Lomas, D. A., MacNee, W., Rennard, S., Silverman, E. K., Miller, B. E., Crim, C., Yates, J., ... Celli, B. (2013). Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization. American Journal of Respiratory and Critical Care Medicine, 187(4), 382-386. https://doi.org/10.1164/rccm.201209-1596OC

@article{b774c62d8bf74cf5b0c3333d6d736b0e,

title = "Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization",

abstract = "Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention. Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods:Data fromtheECLIPSEcohortwereused(n=2,112).Death or first hospitalizationwere indexevents;wemeasured change in6MWDin the 12-month period before the event and related change in 6MWD to lungfunctionandSt. George'sRespiratoryQuestionnaire (healthstatus). Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P",

keywords = "6MW, COPD, Death, Hospitalization, MCID",

author = "Jorgen Vestbo and Polkey, {Michael I.} and Spruit, {Martijn A.} and Edwards, {Lisa D.} and Watkins, {Michael L.} and Victor Pinto-Plata and J{\o}rgen Vestbo and Calverley, {Peter M A} and Ruth Tal-Singer and Alvar Agust{\'i} and Bakke, {Per S.} and Coxson, {Harvey O.} and Lomas, {David A.} and William MacNee and Stephen Rennard and Silverman, {Edwin K.} and Miller, {Bruce E.} and Courtney Crim and Julie Yates and Wouters, {Emiel F M} and Bartolome Celli",

year = "2013",

month = feb,

day = "15",

doi = "10.1164/rccm.201209-1596OC",

language = "English",

volume = "187",

pages = "382--386",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1535-4970",

publisher = "American Thoracic Society",

number = "4",

}

Vestbo, J, Polkey, MI, Spruit, MA, Edwards, LD, Watkins, ML, Pinto-Plata, V, Vestbo, J, Calverley, PMA, Tal-Singer, R, Agustí, A, Bakke, PS, Coxson, HO, Lomas, DA, MacNee, W, Rennard, S, Silverman, EK, Miller, BE, Crim, C, Yates, J, Wouters, EFM & Celli, B 2013, 'Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization', American Journal of Respiratory and Critical Care Medicine, vol. 187, no. 4, pp. 382-386. https://doi.org/10.1164/rccm.201209-1596OC

TY - JOUR

T1 - Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization

AU - Vestbo, Jorgen

AU - Polkey, Michael I.

AU - Spruit, Martijn A.

AU - Edwards, Lisa D.

AU - Watkins, Michael L.

AU - Pinto-Plata, Victor

AU - Vestbo, Jørgen

AU - Calverley, Peter M A

AU - Tal-Singer, Ruth

AU - Agustí, Alvar

AU - Bakke, Per S.

AU - Coxson, Harvey O.

AU - Lomas, David A.

AU - MacNee, William

AU - Rennard, Stephen

AU - Silverman, Edwin K.

AU - Miller, Bruce E.

AU - Crim, Courtney

AU - Yates, Julie

AU - Wouters, Emiel F M

AU - Celli, Bartolome

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention. Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods:Data fromtheECLIPSEcohortwereused(n=2,112).Death or first hospitalizationwere indexevents;wemeasured change in6MWDin the 12-month period before the event and related change in 6MWD to lungfunctionandSt. George'sRespiratoryQuestionnaire (healthstatus). Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P

AB - Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention. Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods:Data fromtheECLIPSEcohortwereused(n=2,112).Death or first hospitalizationwere indexevents;wemeasured change in6MWDin the 12-month period before the event and related change in 6MWD to lungfunctionandSt. George'sRespiratoryQuestionnaire (healthstatus). Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P

KW - 6MW

KW - COPD

KW - Death

KW - Hospitalization

KW - MCID

U2 - 10.1164/rccm.201209-1596OC

DO - 10.1164/rccm.201209-1596OC

M3 - Article

C2 - 23262518

SN - 1535-4970

VL - 187

SP - 382

EP - 386

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 4

ER -

Six-minute-walk test in chronic obstructive pulmonary disease: Minimal clinically important difference for death or hospitalization

Abstract

Keywords

Access to Document

Fingerprint

Cite this