TY - JOUR
T1 - SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer.
AU - Lancellotta, Valentina
AU - Guinot, Jose Luis
AU - Fionda, Bruno
AU - Rembielak, Agata
AU - Stefanini, Alessandro
AU - Gentileschi, Stefano
AU - Federico, Francesco
AU - Rossi, Ernesto
AU - Guix, Benjamin
AU - Jan Chyrek, Artur
AU - Mir, Romaana
AU - Arenas, Meritxell
AU - Rodriguez-Villalba, Silvia
AU - Colloca, Giuseppe Ferdinando
AU - Dinapoli, Nicola
AU - Masciocchi, Carlotta
AU - Lenkowic, Jacopo
AU - Capocchiano, Nicola Dino
AU - Damiani, Andrea
AU - Valentini, Vincenzo
AU - Kovacs, Gyorgy
AU - Tagliaferri, Luca
PY - 2020/4/30
Y1 - 2020/4/30
N2 - Purpose:The primary objective of the SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology is to define a specific terminological system to standardize data collection for non-melanoma skin cancer patients treated with brachytherapy (BT, interventional radiotherapy). Through ontological characterization of information, it is possible to find, isolate, organize, and integrate its meaning. Material and methods:SKIN-COBRA is a standardized data collection consortium for non-melanoma skin patients treated with BT, including 8 cancer centers. Its ontology was firstly defined by a multicentric and multidisciplinary working group and evaluated by the consortium, followed by a multi-professional technical commission involving a mathematician, an engineer, a physician with experience in data storage, a programmer, and a software expert. Results:Two hundred and ninety variables were defined in 10 input forms. There are 3 levels, with each offering a specific type of analysis: 1. Registry level (epidemiology analysis); 2. Procedures level (standard oncology analysis); 3. Research level (radiomics analysis). The ontology was approved by the technical commission and consortium, and an ad-hoc software system was defined to be implemented in the SKIN-COBRA consortium. Conclusions:Large databases are natural extension of traditional statistical approaches, a valuable and increasingly necessary tool for modern healthcare system. Future analysis of the collected multinational and multicenter data will show whether the use of the system can produce high-quality evidence to support multidisciplinary management of non-melanoma skin cancer and utilizing this information for personalized treatment decisions.
AB - Purpose:The primary objective of the SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology is to define a specific terminological system to standardize data collection for non-melanoma skin cancer patients treated with brachytherapy (BT, interventional radiotherapy). Through ontological characterization of information, it is possible to find, isolate, organize, and integrate its meaning. Material and methods:SKIN-COBRA is a standardized data collection consortium for non-melanoma skin patients treated with BT, including 8 cancer centers. Its ontology was firstly defined by a multicentric and multidisciplinary working group and evaluated by the consortium, followed by a multi-professional technical commission involving a mathematician, an engineer, a physician with experience in data storage, a programmer, and a software expert. Results:Two hundred and ninety variables were defined in 10 input forms. There are 3 levels, with each offering a specific type of analysis: 1. Registry level (epidemiology analysis); 2. Procedures level (standard oncology analysis); 3. Research level (radiomics analysis). The ontology was approved by the technical commission and consortium, and an ad-hoc software system was defined to be implemented in the SKIN-COBRA consortium. Conclusions:Large databases are natural extension of traditional statistical approaches, a valuable and increasingly necessary tool for modern healthcare system. Future analysis of the collected multinational and multicenter data will show whether the use of the system can produce high-quality evidence to support multidisciplinary management of non-melanoma skin cancer and utilizing this information for personalized treatment decisions.
UR - https://europepmc.org/articles/PMC7207239
U2 - 10.5114/jcb.2020.94579
DO - 10.5114/jcb.2020.94579
M3 - Article
C2 - 32395133
SN - 1689-832X
JO - Journal of contemporary brachytherapy
JF - Journal of contemporary brachytherapy
ER -
