TY - JOUR
T1 - Skin surface topography grading is a valid measure of skin photoaging
AU - Battistutta, Diana
AU - Pandeya, Nirmala
AU - Strutton, Geoffrey M.
AU - Fourtanier, Anny
AU - Tison, Sylvie
AU - Green, Adèle C.
PY - 2006/2
Y1 - 2006/2
N2 - Background: The technique of grading the surface topography of sun-exposed skin using silicone impressions of the skin surface is a simple, non-invasive method for measuring skin damage because of sun exposure, but it has never been validated in a community setting. Objective: To investigate the repeatability and validity of using standardly-graded skin impressions as a means of assessing skin Photoaging. Patients/Methods: A random sample of 195 adults aged 18-79 years and living in Nambour, Australia (latitude, 26° South) had a silicone impression taken of the back of the left hand and a 2 mm punch biopsy of the skin at the same site. Silicone impressions were graded twice independently and histological photoaging was determined by two pathologists. Results: Grading of silicone impressions of skin surface topography was highly repeatable (weighted κ>0.8). Compared with those with low skin impression grades (least degeneration), people with high grades were three times more likely to show a high degree of dermal elastosis on skin histology (odds ratio 3.1, 95% confidence interval 1.6, 5.7) after adjusting for age, sex, skin colour, tanning ability, occupational exposure, smoking and height-adjusted weight. Other photoaging changes in the stratum corneum and dermis were also strongly correlated with high grades of damage on skin impressions. Conclusion: Grading silicone impressions of skin surface topography is a highly reliable and a valid measure of photoaging and enables prediction of dermal elastosis in a population setting. Copyright © Blackwell Munksgaard 2006.
AB - Background: The technique of grading the surface topography of sun-exposed skin using silicone impressions of the skin surface is a simple, non-invasive method for measuring skin damage because of sun exposure, but it has never been validated in a community setting. Objective: To investigate the repeatability and validity of using standardly-graded skin impressions as a means of assessing skin Photoaging. Patients/Methods: A random sample of 195 adults aged 18-79 years and living in Nambour, Australia (latitude, 26° South) had a silicone impression taken of the back of the left hand and a 2 mm punch biopsy of the skin at the same site. Silicone impressions were graded twice independently and histological photoaging was determined by two pathologists. Results: Grading of silicone impressions of skin surface topography was highly repeatable (weighted κ>0.8). Compared with those with low skin impression grades (least degeneration), people with high grades were three times more likely to show a high degree of dermal elastosis on skin histology (odds ratio 3.1, 95% confidence interval 1.6, 5.7) after adjusting for age, sex, skin colour, tanning ability, occupational exposure, smoking and height-adjusted weight. Other photoaging changes in the stratum corneum and dermis were also strongly correlated with high grades of damage on skin impressions. Conclusion: Grading silicone impressions of skin surface topography is a highly reliable and a valid measure of photoaging and enables prediction of dermal elastosis in a population setting. Copyright © Blackwell Munksgaard 2006.
KW - Dermal elastosis
KW - Photoaging
KW - Skin surface topography
KW - Ultraviolet radiation
U2 - 10.1111/j.1600-0781.2006.00194.x
DO - 10.1111/j.1600-0781.2006.00194.x
M3 - Article
C2 - 16436180
SN - 1600-0781
VL - 22
SP - 39
EP - 45
JO - Photodermatology Photoimmunology and Photomedicine
JF - Photodermatology Photoimmunology and Photomedicine
IS - 1
ER -