SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample

Jonathan Green, Francesca Blasi, Elena Bacchelli, Simona Carone, Claudio Toma, Anthony P. Monaco, Anthony J. Bailey, Elena Maestrini, Janine Lamb

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Autism is a severe neurodevelopmental disorder with a complex genetic predisposition. Linkage findings from several genome scans suggest the presence of an autism susceptibility locus on chromosome 2q24-q33, making this region the focus of candidate gene and association studies. Recently, significant association with autism has been reported for single-nucleotide polymorphisms (SNPs) in the SLC25A12 and CMYA3 genes on chromosome 2q. We attempted to replicate these findings in the collection of families from the International Molecular Genetic Study of Autism Consortium (IMGSAC), using the transmission disequilibrium test and case-control comparison. Our study failed to reveal any significant association for the SNPs tested at either locus, suggesting that these variants are unlikely to play a major role in genetic susceptibility to autism in our sample. © 2006 Nature Publishing Group. All rights reserved.
    Original languageEnglish
    Pages (from-to)123-126
    Number of pages3
    JournalEuropean Journal of Human Genetics
    Volume14
    Issue number1
    DOIs
    Publication statusPublished - Jan 2006

    Keywords

    • Association
    • Autism
    • Chromosome 2q
    • CMYA3
    • SLC25A12
    • SNPs

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