TY - JOUR
T1 - Sleep disturbance in bipolar disorder
T2 - Neuroglia and circadian rhythms
AU - Steardo, Luca J.
AU - De Filippis, Renato
AU - Carbone, Elvira Anna
AU - Segura-Garcia, Cristina
AU - Verkhratsky, Alexei
AU - De Fazio, Pasquale
PY - 2019/7/18
Y1 - 2019/7/18
N2 - The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity. The BD syndrome also involves heterogeneous symptomatology, including cognitive dysfunctions and impairments of the autonomic nervous system. Sleep abnormalities are frequently associated with BD and are often a good predictor of a mood swing. Preservation of stable sleep–wake cycles is therefore a key to the maintenance of stability in BD, indicating the crucial role of circadian rhythms in this syndrome. The symptom most widespread in BD is insomnia, followed by excessive daytime sleepiness, nightmares, difficulty falling asleep or maintaining sleep, poor sleep quality, sleep talking, sleep walking, and obstructive sleep apnea. Alterations in the structure or duration of sleep are reported in all phases of BD. Understanding the role of neuroglia in BD and in various aspects of sleep is in nascent state. Contributions of the different types of glial cells to BD and sleep abnormalities are discussed in this paper.
AB - The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity. The BD syndrome also involves heterogeneous symptomatology, including cognitive dysfunctions and impairments of the autonomic nervous system. Sleep abnormalities are frequently associated with BD and are often a good predictor of a mood swing. Preservation of stable sleep–wake cycles is therefore a key to the maintenance of stability in BD, indicating the crucial role of circadian rhythms in this syndrome. The symptom most widespread in BD is insomnia, followed by excessive daytime sleepiness, nightmares, difficulty falling asleep or maintaining sleep, poor sleep quality, sleep talking, sleep walking, and obstructive sleep apnea. Alterations in the structure or duration of sleep are reported in all phases of BD. Understanding the role of neuroglia in BD and in various aspects of sleep is in nascent state. Contributions of the different types of glial cells to BD and sleep abnormalities are discussed in this paper.
KW - Astroglia
KW - Bipolar Disorder
KW - Depressive behavior
KW - Microglia
KW - Oligodendroglia
U2 - 10.3389/fpsyt.2019.00501
DO - 10.3389/fpsyt.2019.00501
M3 - Review article
AN - SCOPUS:85069177946
SN - 1664-0640
VL - 10
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
IS - JUN
M1 - 501
ER -