SMARCE1 mutations in pediatric clear cell meningioma: case report

Linton T Evans, Jack Van Hoff, William F Hickey, Miriam J Smith, Gareth Evans, William G Newman, David F Bauer

Research output: Contribution to journalArticlepeer-review


Clear cell meningioma (CCM) is an uncommon variant of meningioma. The authors describe a case of a pediatric CCM localized to the lumbar spine. After resection, sequencing revealed an inactivating mutation in the SWI/SNF chromatin remodeling complex subunit SMARCE1, with loss of the second allele in the tumor. The authors present a literature review of this mutation that is associated with CCM and a family history of spine tumors.
Original languageEnglish
JournalJournal of neurosurgery. Pediatrics
Issue number3
Publication statusPublished - Jun 2015


  • CCM = clear cell meningioma
  • NF2 = neurofibromatosis Type 2
  • clear cell meningioma
  • oncology


Dive into the research topics of 'SMARCE1 mutations in pediatric clear cell meningioma: case report'. Together they form a unique fingerprint.

Cite this