Smart Fluoride- and Chloride-Containing Bioactive Glasses for Dental Applications

Xiaojing Chen, Catherine Kenny, Xiaohui Chen, Natalia Karpukhina, Robert Hill

Research output: Contribution to conferenceAbstractpeer-review


Objectives: To investigate the abilities of glass degradation and fluorapatite tooth mineral formation for mixed fluoride- and chloride-containing bioactive glasses in vitro and their cutting efficiency of dentine using air abrasion.
Methods: Mixed fluoride- and chloride-containing glasses were synthesized using a melt-quench method. Glass transition temperature (Tg) was evaluated by differential scanning calorimetry. Glass bioactivity was investigated by the immersion of glass powders in Tris buffer solution and apatite formation was followed by X-ray diffraction, fourier transform infrared spectroscopy and magic angle spinning-nuclear magnetic resonance. Inductively coupled plasma-optical emission spectroscopy was employed to quantify the amount of ions released. The powdered glasses with particle sizes between 38 and 90μm were used for air abrasion on dentine. The cutting efficiency was evaluated by using white light profilometry and scanning electron microscope.
Results: These smart glasses were highly degradable and able to form fluorapatite within 3h of immersion. The formation of CaF2 was noticed in the high fluoride-containing bioactive glasses. Faster glass degradation was evidenced in the higher chloride-containing glasses. DSC results demonstrated a significant reduction of Tg with increasing calcium halide content. Air abrasion on dentine using the low and intermediate chloride-containing glasses demonstrated clear depressions, while no depression was found using the high chloride-containing glass.
Conclusions: This study revealed that the glasses with mixed fluoride and chloride integrate the benefits from the presence of both, showing rapid glass degradation and fluorapatite formation. An increase in the CaCl2 content led to a remarkable decrease in Tg, suggesting a reduction of glass hardness. Furthermore, a series of glasses with low fluoride and various chloride contents are able to selectively cut dental tissues. Therefore, these compelling bioactive halide-containing glasses are attractive for dental applications.
Original languageEnglish
Publication statusPublished - 26 Jul 2018
Event2018 IADR/PER General Session (London, England) - London, United Kingdom
Duration: 25 Jul 201828 Jul 2018


Conference2018 IADR/PER General Session (London, England)
Country/TerritoryUnited Kingdom


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