So you can teach old fibroblasts new tricks

Amaya Viros Usandizaga, Maria Romina Girotti, Richard Marais

Research output: Contribution to journalArticlepeer-review


New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalCancer discovery
Issue number6
Publication statusPublished - 1 Jun 2016

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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