So you can teach old fibroblasts new tricks

Amaya Viros Usandizaga; Maria Romina Girotti; Richard Marais

doi:10.1158/2159-8290.CD-16-0503

So you can teach old fibroblasts new tricks

Amaya Viros Usandizaga, Maria Romina Girotti, Richard Marais

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior.

Original language	English
Pages (from-to)	581-583
Number of pages	3
Journal	Cancer discovery
Volume	6
Issue number	6
DOIs	https://doi.org/10.1158/2159-8290.CD-16-0503
Publication status	Published - 1 Jun 2016

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/2159-8290.CD-16-0503

Cite this

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title = "So you can teach old fibroblasts new tricks",

abstract = "New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior.",

author = "{Viros Usandizaga}, Amaya and Girotti, {Maria Romina} and Richard Marais",

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AU - Marais, Richard

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N2 - New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior.

AB - New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior.

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So you can teach old fibroblasts new tricks

Abstract

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UN SDGs

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