Solubility study of tobramycin in room temperature ionic liquids: An experimental and computational based study

Christopher Hardacre, Richard Cunningham, Nancy Forero-Martinez, Tristan G. A. Youngs, Marie E. Migaud

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    Abstract

    Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]-, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.
    Original languageEnglish
    Pages (from-to)107214-107218
    Number of pages5
    JournalRSC Advances
    Volume6
    Issue number109
    Early online date4 Nov 2016
    DOIs
    Publication statusPublished - 2016

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