Solution-mediated transformation of α to β L-glutamic acid: Rate enhancement due to secondary nucleation

Elena S. Ferrari; Roger J. Davey

doi:10.1021/cg0342112

Solution-mediated transformation of α to β L-glutamic acid: Rate enhancement due to secondary nucleation

Research output: Contribution to journal › Article › peer-review

Abstract

The ability to control the transformation process between polymorphs of crystalline materials is critical to ensure that the correct form is produced, and hence it is essential to learn which experimental factors affect this transformation reaction. In this contribution, the kinetics of the polymorphic transformation between metastable and stable forms of L-glutamic acid was studied using a number of techniques: optical microscopy, FT-IR, Raman and UV spectroscopy. The effects of solution composition and in particular process scale were investigated. The role of secondary nucleation in which the surface of one polymorph acts as a template for the nucleation of another form is highlighted in this paper.

Original language	English
Pages (from-to)	1061-1068
Number of pages	7
Journal	Crystal Growth and Design
Volume	4
Issue number	5
DOIs	https://doi.org/10.1021/cg0342112
Publication status	Published - Sept 2004

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abstract = "The ability to control the transformation process between polymorphs of crystalline materials is critical to ensure that the correct form is produced, and hence it is essential to learn which experimental factors affect this transformation reaction. In this contribution, the kinetics of the polymorphic transformation between metastable and stable forms of L-glutamic acid was studied using a number of techniques: optical microscopy, FT-IR, Raman and UV spectroscopy. The effects of solution composition and in particular process scale were investigated. The role of secondary nucleation in which the surface of one polymorph acts as a template for the nucleation of another form is highlighted in this paper.",

author = "Ferrari, {Elena S.} and Davey, {Roger J.}",

note = "Times Cited: 37 6th International Conference on the Crystal Growth of Organic Materials Sep 18-21, 2003 Univ Strathclyde, Glasgow, SCOTLAND",

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AU - Davey, Roger J.

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PY - 2004/9

Y1 - 2004/9

N2 - The ability to control the transformation process between polymorphs of crystalline materials is critical to ensure that the correct form is produced, and hence it is essential to learn which experimental factors affect this transformation reaction. In this contribution, the kinetics of the polymorphic transformation between metastable and stable forms of L-glutamic acid was studied using a number of techniques: optical microscopy, FT-IR, Raman and UV spectroscopy. The effects of solution composition and in particular process scale were investigated. The role of secondary nucleation in which the surface of one polymorph acts as a template for the nucleation of another form is highlighted in this paper.

AB - The ability to control the transformation process between polymorphs of crystalline materials is critical to ensure that the correct form is produced, and hence it is essential to learn which experimental factors affect this transformation reaction. In this contribution, the kinetics of the polymorphic transformation between metastable and stable forms of L-glutamic acid was studied using a number of techniques: optical microscopy, FT-IR, Raman and UV spectroscopy. The effects of solution composition and in particular process scale were investigated. The role of secondary nucleation in which the surface of one polymorph acts as a template for the nucleation of another form is highlighted in this paper.

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Solution-mediated transformation of α to β L-glutamic acid: Rate enhancement due to secondary nucleation

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