Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

Gemma Texidó; Heinz Jacobs; Myriam Meiering; Ralf Kühn; Jürgen Roes; Werner Müller; Susan Gilfillan; Hiroshi Fujiwara; Hitoshi Kikutani; Nobuaki Yoshida; Ryuichi Amakawa; Christophe Benoist; Diane Mathis; Tadamitsu Kishimoto; Tak W. Mak; Klaus Rajewsky

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

Gemma Texidó, Heinz Jacobs, Myriam Meiering, Ralf Kühn, Jürgen Roes, Werner Müller, Susan Gilfillan, Hiroshi Fujiwara, Hitoshi Kikutani, Nobuaki Yoshida, Ryuichi Amakawa, Christophe Benoist, Diane Mathis, Tadamitsu Kishimoto, Tak W. Mak, Klaus Rajewsky

Research output: Contribution to journal › Article › peer-review

Abstract

We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation.

Original language	English
Pages (from-to)	1966-1969
Number of pages	3
Journal	European journal of immunology
Volume	26
Issue number	8
Publication status	Published - 1996

Keywords

CD23
Hypermutation
IgD
Interleukin-4
Terminal deoxynucleotidyl transferase

Cite this

Texidó, G., Jacobs, H., Meiering, M., Kühn, R., Roes, J., Müller, W., Gilfillan, S., Fujiwara, H., Kikutani, H., Yoshida, N., Amakawa, R., Benoist, C., Mathis, D., Kishimoto, T., Mak, T. W., & Rajewsky, K. (1996). Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants. European journal of immunology, 26(8), 1966-1969.

@article{069b4fef50274a328fbb05b5b77f6890,

title = "Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants",

abstract = "We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation.",

keywords = "CD23, Hypermutation, IgD, Interleukin-4, Terminal deoxynucleotidyl transferase",

author = "Gemma Texid{\'o} and Heinz Jacobs and Myriam Meiering and Ralf K{\"u}hn and J{\"u}rgen Roes and Werner M{\"u}ller and Susan Gilfillan and Hiroshi Fujiwara and Hitoshi Kikutani and Nobuaki Yoshida and Ryuichi Amakawa and Christophe Benoist and Diane Mathis and Tadamitsu Kishimoto and Mak, {Tak W.} and Klaus Rajewsky",

year = "1996",

language = "English",

volume = "26",

pages = "1966--1969",

journal = "European journal of immunology",

issn = "1521-4141",

publisher = "John Wiley & Sons Ltd",

number = "8",

}

Texidó, G, Jacobs, H, Meiering, M, Kühn, R, Roes, J, Müller, W, Gilfillan, S, Fujiwara, H, Kikutani, H, Yoshida, N, Amakawa, R, Benoist, C, Mathis, D, Kishimoto, T, Mak, TW & Rajewsky, K 1996, 'Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants', European journal of immunology, vol. 26, no. 8, pp. 1966-1969.

TY - JOUR

T1 - Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

AU - Texidó, Gemma

AU - Jacobs, Heinz

AU - Meiering, Myriam

AU - Kühn, Ralf

AU - Roes, Jürgen

AU - Müller, Werner

AU - Gilfillan, Susan

AU - Fujiwara, Hiroshi

AU - Kikutani, Hitoshi

AU - Yoshida, Nobuaki

AU - Amakawa, Ryuichi

AU - Benoist, Christophe

AU - Mathis, Diane

AU - Kishimoto, Tadamitsu

AU - Mak, Tak W.

AU - Rajewsky, Klaus

PY - 1996

Y1 - 1996

N2 - We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation.

AB - We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation.

KW - CD23

KW - Hypermutation

KW - IgD

KW - Interleukin-4

KW - Terminal deoxynucleotidyl transferase

M3 - Article

C2 - 8765046

SN - 1521-4141

VL - 26

SP - 1966

EP - 1969

JO - European journal of immunology

JF - European journal of immunology

IS - 8

ER -

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

Abstract

Keywords

Fingerprint

Cite this