Something Old, Something New: The Tumor Microenvironment Comes of Age

K.L. Marie; Glenn Merlino

doi:10.1158/2159-8290.cd-18-1320

Something Old, Something New: The Tumor Microenvironment Comes of Age

K.L. Marie
, Glenn Merlino

Division of Molecular & Cellular Function (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

In this issue, Weeraratna and colleagues demonstrate that observed differences in melanoma aggressiveness in younger versus older patients can be explained not just by cell-intrinsic alterations over time, but by age-dependent changes in fibroblasts and the extracellular matrix they help create. Their findings identify novel cellular targets for melanoma therapy, as well as candidate prognostic biomarkers to better inform clinical decisions for patients with melanoma.

Original language	English
Pages (from-to)	19–21
Number of pages	3
Journal	Cancer discovery
Volume	9
Issue number	1
DOIs	https://doi.org/10.1158/2159-8290.cd-18-1320
Publication status	Published - 1 Jan 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1158/2159-8290.cd-18-1320

Cite this

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title = "Something Old, Something New: The Tumor Microenvironment Comes of Age",

abstract = "In this issue, Weeraratna and colleagues demonstrate that observed differences in melanoma aggressiveness in younger versus older patients can be explained not just by cell-intrinsic alterations over time, but by age-dependent changes in fibroblasts and the extracellular matrix they help create. Their findings identify novel cellular targets for melanoma therapy, as well as candidate prognostic biomarkers to better inform clinical decisions for patients with melanoma. ",

author = "K.L. Marie and Glenn Merlino",

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doi = "10.1158/2159-8290.cd-18-1320",

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N2 - In this issue, Weeraratna and colleagues demonstrate that observed differences in melanoma aggressiveness in younger versus older patients can be explained not just by cell-intrinsic alterations over time, but by age-dependent changes in fibroblasts and the extracellular matrix they help create. Their findings identify novel cellular targets for melanoma therapy, as well as candidate prognostic biomarkers to better inform clinical decisions for patients with melanoma.

AB - In this issue, Weeraratna and colleagues demonstrate that observed differences in melanoma aggressiveness in younger versus older patients can be explained not just by cell-intrinsic alterations over time, but by age-dependent changes in fibroblasts and the extracellular matrix they help create. Their findings identify novel cellular targets for melanoma therapy, as well as candidate prognostic biomarkers to better inform clinical decisions for patients with melanoma.

UR - http://dx.doi.org/10.1158/2159-8290.cd-18-1320

U2 - 10.1158/2159-8290.cd-18-1320

DO - 10.1158/2159-8290.cd-18-1320

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VL - 9

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JO - Cancer discovery

JF - Cancer discovery

IS - 1

ER -

Something Old, Something New: The Tumor Microenvironment Comes of Age

Abstract

UN SDGs

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