SOXF transcription factors in cardiovascular development

Andrew J Lilly; Georges Lacaud; Valerie Kouskoff

doi:10.1016/j.semcdb.2016.07.021

SOXF transcription factors in cardiovascular development

Andrew J Lilly, Georges Lacaud, Valerie Kouskoff

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Abstract

Cardiovascular development during embryogenesis involves complex changes in gene regulatory networks regulated by a variety of transcription factors. In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and lymphatic development. SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation between SOXF family members. Despite this, evidence suggests that there is some specificity in the transcriptional programs they regulate which is necessary to control the differentiation and behaviour of endothelial subpopulations. Furthermore, SOXF factors appear to have an indirect role in regulating cardiac mesoderm specification and differentiation. Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Seminars in cell & developmental biology
Volume	63
Early online date	25 Jul 2016
DOIs	https://doi.org/10.1016/j.semcdb.2016.07.021
Publication status	Published - 2016

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10.1016/j.semcdb.2016.07.021

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title = "SOXF transcription factors in cardiovascular development",

abstract = "Cardiovascular development during embryogenesis involves complex changes in gene regulatory networks regulated by a variety of transcription factors. In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and lymphatic development. SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation between SOXF family members. Despite this, evidence suggests that there is some specificity in the transcriptional programs they regulate which is necessary to control the differentiation and behaviour of endothelial subpopulations. Furthermore, SOXF factors appear to have an indirect role in regulating cardiac mesoderm specification and differentiation. Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases.",

author = "Lilly, {Andrew J} and Georges Lacaud and Valerie Kouskoff",

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AU - Lilly, Andrew J

AU - Lacaud, Georges

AU - Kouskoff, Valerie

PY - 2016

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AB - Cardiovascular development during embryogenesis involves complex changes in gene regulatory networks regulated by a variety of transcription factors. In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and lymphatic development. SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation between SOXF family members. Despite this, evidence suggests that there is some specificity in the transcriptional programs they regulate which is necessary to control the differentiation and behaviour of endothelial subpopulations. Furthermore, SOXF factors appear to have an indirect role in regulating cardiac mesoderm specification and differentiation. Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases.

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DO - 10.1016/j.semcdb.2016.07.021

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VL - 63

SP - 50

EP - 57

JO - Seminars in cell & developmental biology

JF - Seminars in cell & developmental biology

ER -

SOXF transcription factors in cardiovascular development

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