Spatially resolved ultra-trace analysis of elements combining resonance ionization with a MALDI-TOF spectrometer

Jochen Maul; Ilia Strachnov; Klaus Eberhardt; Sergej Karpuk; Gerd Passler; Norbert Trautmann; Klaus Wendt; Gerhard Huber

doi:10.1007/s00216-006-0584-1

Spatially resolved ultra-trace analysis of elements combining resonance ionization with a MALDI-TOF spectrometer

Jochen Maul^*, Ilia Strachnov, Klaus Eberhardt, Sergej Karpuk, Gerd Passler, Norbert Trautmann, Klaus Wendt, Gerhard Huber

^*Corresponding author for this work

Johannes Gutenberg-Universitat Mainz

Research output: Contribution to journal › Article › peer-review

Abstract

A combined setup for spatially resolved mass analysis of trace amounts of elements and macromolecules is presented. Using a MALDI-TOF mass spectrometer, a laser spectroscopic setup for resonant ionization of neutral atoms has been implemented. This allows for an efficient and selective detection of trace elements by means of resonance ionization mass spectrometry (RIMS). The instrumental scheme is described, and methodological developments are presented. In a first application pure, laser desorption/ionization with TOF-MS was used to measure mass distributions of cosmic nanodiamonds. For further applications regarding the spatially resolved ultra-trace analysis of elements in solid samples, an implanted target was used to characterize both laser desorption/ionization and laser desorption/resonance ionization for the detection of trace elements within. A perspective of the setup is given and future investigations are outlined.

Original language	English
Pages (from-to)	109-118
Number of pages	10
Journal	Analytical and bioanalytical chemistry
Volume	386
Issue number	1
DOIs	https://doi.org/10.1007/s00216-006-0584-1
Publication status	Published - 18 Jul 2006

Keywords

Laser desorption/ionization
MALDI-TOF
Proteomics
Resonance ionization mass spectrometry (RIMS)
Resonance ionization spectroscopy (RIS)
Ultra-trace analysis

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10.1007/s00216-006-0584-1

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title = "Spatially resolved ultra-trace analysis of elements combining resonance ionization with a MALDI-TOF spectrometer",

abstract = "A combined setup for spatially resolved mass analysis of trace amounts of elements and macromolecules is presented. Using a MALDI-TOF mass spectrometer, a laser spectroscopic setup for resonant ionization of neutral atoms has been implemented. This allows for an efficient and selective detection of trace elements by means of resonance ionization mass spectrometry (RIMS). The instrumental scheme is described, and methodological developments are presented. In a first application pure, laser desorption/ionization with TOF-MS was used to measure mass distributions of cosmic nanodiamonds. For further applications regarding the spatially resolved ultra-trace analysis of elements in solid samples, an implanted target was used to characterize both laser desorption/ionization and laser desorption/resonance ionization for the detection of trace elements within. A perspective of the setup is given and future investigations are outlined.",

keywords = "Laser desorption/ionization, MALDI-TOF, Proteomics, Resonance ionization mass spectrometry (RIMS), Resonance ionization spectroscopy (RIS), Ultra-trace analysis",

author = "Jochen Maul and Ilia Strachnov and Klaus Eberhardt and Sergej Karpuk and Gerd Passler and Norbert Trautmann and Klaus Wendt and Gerhard Huber",

note = "Funding Information: Acknowledgements The Deutsche Forschungsgemeinschaft (DFG) and the Zentrum f{\"u}r Umweltforschung Rheinland-Pfalz (ZfU) are acknowledged for financial support, as well as the Graduiertenkolleg “Elementspeziation” at the Johannes Gutenberg-Universit{\"a}t Mainz. We also would like to thank M. Sch{\"u}renberg, J. H{\"o}hndorf and A. Holle (Bruker Daltonia, Bremen), and A. Asperger and V. Sauerland (Bruker Saxonia, Leipzig) for kind assistance during the study. G. Pensl and W. R{\"o}sch (Universit{\"a}t Erlangen) are gratefully acknowledged for the preparation of implanted targets. Furthermore, T. Berg, I. Hoog, K.-J. Kott, J. Lassen, M.C. Roca-Sa{\'i}z, F. Schertz, and K. Wollenberg are thanked for their assistance.",

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doi = "10.1007/s00216-006-0584-1",

language = "English",

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T1 - Spatially resolved ultra-trace analysis of elements combining resonance ionization with a MALDI-TOF spectrometer

AU - Maul, Jochen

AU - Strachnov, Ilia

AU - Eberhardt, Klaus

AU - Karpuk, Sergej

AU - Passler, Gerd

AU - Trautmann, Norbert

AU - Wendt, Klaus

AU - Huber, Gerhard

N1 - Funding Information: Acknowledgements The Deutsche Forschungsgemeinschaft (DFG) and the Zentrum für Umweltforschung Rheinland-Pfalz (ZfU) are acknowledged for financial support, as well as the Graduiertenkolleg “Elementspeziation” at the Johannes Gutenberg-Universität Mainz. We also would like to thank M. Schürenberg, J. Höhndorf and A. Holle (Bruker Daltonia, Bremen), and A. Asperger and V. Sauerland (Bruker Saxonia, Leipzig) for kind assistance during the study. G. Pensl and W. Rösch (Universität Erlangen) are gratefully acknowledged for the preparation of implanted targets. Furthermore, T. Berg, I. Hoog, K.-J. Kott, J. Lassen, M.C. Roca-Saíz, F. Schertz, and K. Wollenberg are thanked for their assistance.

PY - 2006/7/18

Y1 - 2006/7/18

N2 - A combined setup for spatially resolved mass analysis of trace amounts of elements and macromolecules is presented. Using a MALDI-TOF mass spectrometer, a laser spectroscopic setup for resonant ionization of neutral atoms has been implemented. This allows for an efficient and selective detection of trace elements by means of resonance ionization mass spectrometry (RIMS). The instrumental scheme is described, and methodological developments are presented. In a first application pure, laser desorption/ionization with TOF-MS was used to measure mass distributions of cosmic nanodiamonds. For further applications regarding the spatially resolved ultra-trace analysis of elements in solid samples, an implanted target was used to characterize both laser desorption/ionization and laser desorption/resonance ionization for the detection of trace elements within. A perspective of the setup is given and future investigations are outlined.

AB - A combined setup for spatially resolved mass analysis of trace amounts of elements and macromolecules is presented. Using a MALDI-TOF mass spectrometer, a laser spectroscopic setup for resonant ionization of neutral atoms has been implemented. This allows for an efficient and selective detection of trace elements by means of resonance ionization mass spectrometry (RIMS). The instrumental scheme is described, and methodological developments are presented. In a first application pure, laser desorption/ionization with TOF-MS was used to measure mass distributions of cosmic nanodiamonds. For further applications regarding the spatially resolved ultra-trace analysis of elements in solid samples, an implanted target was used to characterize both laser desorption/ionization and laser desorption/resonance ionization for the detection of trace elements within. A perspective of the setup is given and future investigations are outlined.

KW - Laser desorption/ionization

KW - MALDI-TOF

KW - Proteomics

KW - Resonance ionization mass spectrometry (RIMS)

KW - Resonance ionization spectroscopy (RIS)

KW - Ultra-trace analysis

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M3 - Article

AN - SCOPUS:33747584368

SN - 1618-2642

VL - 386

SP - 109

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JO - Analytical and bioanalytical chemistry

JF - Analytical and bioanalytical chemistry

IS - 1

ER -

Spatially resolved ultra-trace analysis of elements combining resonance ionization with a MALDI-TOF spectrometer

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Keywords

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