Spatio-temporal protein dynamics in single living cells

John M. Ankers, Dave G. Spiller, Michael RH White, Claire V. Harper

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    Abstract

    The development and application of single cell optical imaging has identified dynamic and oscillatory signalling processes in individual cells. This requires single cell analyses since the processes may otherwise be masked by the population average. These oscillations range in timing from seconds/minutes (e.g. calcium) to minutes/hours (e.g. NF-κB, Notch/Wnt and p53) and hours/days (e.g. circadian clock and cell cycle). Quantitative live cell measurement of the protein processes underlying these complex networks will allow characterisation of the core mechanisms that drive these signalling pathways and control cell function. Ultimately, such studies can be applied to develop predictive models of whole tissues and organisms. © 2008 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)375-380
    Number of pages5
    JournalCurrent Opinion in Biotechnology
    Volume19
    Issue number4
    DOIs
    Publication statusPublished - Aug 2008

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