Spectral improvement by fourier thresholding of in vivo dynamic spectroscopy data

Benjamin Rowland, Sai K Merugumala, Huijun Liao, Mark A Creager, James Balschi, Alexander P Lin

Research output: Contribution to journalArticlepeer-review


PURPOSE: MR spectroscopy (MRS) typically requires averaging of multiple acquisitions to achieve adequate signal-to-noise ratio (SNR). In systems undergoing dynamic changes this can compromise the temporal resolution of the measurement. One such example is (31) P MRS of exercising skeletal muscle. Spectral improvement by Fourier thresholding (SIFT) offers a way of suppressing noise without averaging. In this study, we evaluate the performance of SIFT in healthy subjects and clinical cases.

METHODS: (31) P MRS of the calf or thigh muscle of subjects (n = 12) was measured continuously before, during, and after exercise. The data were processed conventionally and with the addition of SIFT before quantifying peak amplitudes and frequencies. The postexercise increase in the amplitude of phosphocreatine was also characterized by fitting with an exponential function to obtain the recovery time constant.

RESULTS: Substantial reductions in the uncertainty of peak fitting for phosphocreatine (73%) and inorganic phosphate (60%) were observed when using SIFT relative to conventional processing alone. SIFT also reduced the phosphocreatine recovery time constant uncertainty by 38%.

CONCLUSION: SIFT considerably improves SNR, which improved quantification and parameter estimation. It is suitable for any type of time varying MRS and is both straightforward and fast to apply. Magn Reson Med 76:978-985, 2016. © 2015 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)978-85
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number3
Early online date7 Oct 2015
Publication statusPublished - Sept 2016


  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Animals
  • Cattle
  • Energy Metabolism
  • Fourier Analysis
  • Humans
  • Magnetic Resonance Spectroscopy
  • Middle Aged
  • Muscle, Skeletal
  • Phosphates
  • Phosphocreatine
  • Phosphorus Isotopes
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Signal-To-Noise Ratio
  • Journal Article

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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