Squamous-cell carcinoma of the anus: progress in radiotherapy treatment

Rob Glynne-Jones, David Tan, Robert Hughes, Peter Hoskin

Research output: Contribution to journalReview articlepeer-review


Chemoradiotherapy is the standard-of-care treatment of squamous-cell carcinoma of the anus (SCCA), and this has not changed in decades. Radiation doses of 50-60 Gy, as used in many phase III trials, result in substantial late morbidities and fail to control larger and node-positive tumours. Technological advances in radiation therapy are improving patient outcomes and quality of life, and should be applied to patients with SCCA. Modern techniques such as intensity-modulated radiotherapy (IMRT), rotational IMRT, image-guided radiotherapy using cone-beam CT, and stereotactic techniques have enabled smaller margins and highly conformal plans, resulting in decreased radiation doses to the organs at risk and ensuring a shorter overall treatment time. In this Perspectives article, the use of novel approaches to target delineation, optimized radiotherapy techniques, adaptive radiotherapy, dose-escalation with external-beam radiotherapy (EBRT) or brachytherapy, and the potential for modified fractionation are discussed in the context of SCCA.

Original languageEnglish
Pages (from-to)447-59
Number of pages13
JournalNature Reviews. Clinical Oncology
Issue number7
Publication statusPublished - 27 Jan 2016


  • Antineoplastic Combined Chemotherapy Protocols/therapeutic use
  • Anus Neoplasms/radiotherapy
  • Biological Factors/therapeutic use
  • Brachytherapy/methods
  • Carcinoma, Squamous Cell/radiotherapy
  • Chemoradiotherapy/methods
  • Clinical Trials, Phase III as Topic
  • Humans
  • Magnetic Resonance Imaging/methods
  • Organs at Risk
  • Positron Emission Tomography Computed Tomography/methods
  • Proton Therapy/methods
  • Radiotherapy Dosage
  • Radiotherapy, Image-Guided/methods
  • Randomized Controlled Trials as Topic

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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